Fibrillin 1 anticorps

N° du produit ABIN265420

Détail du produit anti-Fibrillin 1 anticorps

Antigène: Fibrillin 1 (FBN1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Fibrillin 1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: This antibody detects endogenous levels of Fibrillin-1 protein. (region surrounding asn2843)

Réactivité croisée (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Affinity Chromatography using epitope-specific immunogen.

Information d'application

Indications d'application: ELISA: 1/40000-1/60000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Stockage

Concentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2, 0.05 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freezing and thawing.

Stock: 4 °C/-20 °C

Stockage commentaire: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Références pour anticorps anti-Fibrillin 1 (ABIN265420)

Bell, Gendron, Anderson, Flatow, Andarawis-Puri: "A potential new role for myofibroblasts in remodeling of sub-rupture fatigue tendon injuries by exercise." dans: Scientific reports, Vol. 8, Issue 1, pp. 8933, (2018) (PubMed).

Détails sur Fibrillin 1

Antigène: Fibrillin 1 (FBN1)

Autre désignation: Fibrillin-1 (FBN1 Produits)

Synonymes: anticorps FBN1, anticorps ACMICD, anticorps ECTOL1, anticorps FBN, anticorps GPHYSD2, anticorps MASS, anticorps MFS1, anticorps OCTD, anticorps SGS, anticorps SSKS, anticorps WMS, anticorps WMS2, anticorps AI536462, anticorps B430209H23, anticorps Fib-1, anticorps Tsk, anticorps fibrillin 1, anticorps FBN1, anticorps Fbn1

Sujet: The fibrillin family of proteins, including fibrillin-1 (FBN1) and fibrillin-2 (FBN2), are integral components of a distinct subset of extracellular microfibrils. Microfibrils are found in elastic tissues where they facilitate elastic fiber formation and in nonelastic tissue where they support the association of the epithelial cells with the interstitial matrix. Characteristic of the fibrillin proteins are the epidermal growth factor (EGF)-like motifs, which contain a consensus sequence for calcium binding. This calcium association may be critical for protein-protein interactions and stabilization of the microfibrils. Mutations of the FBN1 gene have been shown to result in Marfan syndrome, a disease characterized by abnormal synthesis, secretion and matrix deposition of fibrillin. FBN2 is also linked to a rare, yet similiar, skeletal disorder, congenital contractural arachnodactyly.Synonyms: FBN, FBN1

ID gène: 2200

NCBI Accession: NP_000129

UniProt: P35555

Pathways: Maintenance of Protein Location, SARS-CoV-2 Protein Interactome