CSF3R anticorps (PerCP-Cy5.5)

N° du produit ABIN2659931

Détail du produit anti-CSF3R anticorps (PerCP-Cy5.5)

Antigène: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CSF3R est conjugé à/à la PerCP-Cy5.5

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography and conjugated with PerCP/Cy5.5 under optimal conditions. The solution is free of unconjugated PerCP/Cy5.5 and unconjugated antibody.

Clone: LMM741

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CSF3R

Antigène: CSF3R (Colony Stimulating Factor 3 Receptor (Granulocyte) (CSF3R))

Autre désignation: CD114 (CSF3R Produits)

Synonymes: anticorps CD114, anticorps GCSFR, anticorps Cd114, anticorps Csfgr, anticorps G-CSF-R, anticorps G-CSFR, anticorps CSF3R, anticorps gcsfr, anticorps cd114, anticorps colony stimulating factor 3 receptor, anticorps colony stimulating factor 3 receptor (granulocyte), anticorps colony stimulating factor 3 receptor L homeolog, anticorps granulocyte colony-stimulating factor receptor, anticorps CSF3R, anticorps Csf3r, anticorps csf3r, anticorps csf3r.L, anticorps LOC100433338

Sujet: CD114 is the receptor of the colony stimulating factor 3 (CSF3, G-CSF) it consists of two 130 kD, type I transmembrane chains that form a homodimer. The extracellular domain consists of an immunoglobulin-like domain, a cytokine receptor homologue domain, and three fibronectin type III repeats. CD114 is expressed in all stages of granulocyte differentiation and in monocytes, platelets, endothelial cells, placenta and trophoblasts. The binding of CSF3 results in the activation of many signaling molecules such as Syk, Lyn, Jak1, Jak2, Tyk2, SOCS3, SOCS1, STAT5, and Shp1, resulting in the expression of different target genes that will increase neutrophil precursor survival, proliferation and maturation. In mature neutrophils, it increases survival, superoxide anion generation, arachidonic acid release, production of myeloperoxidase and leukocyte alkaline phosphatase (LAP).