IFNB1 anticorps (Biotin)

N° du produit ABIN2661188

Cet anticorps anti-IFNB1 est un anticorps Hamster Monoclonal détectant IFNB1 dans FACS. Adapté pour Souris.

Aperçu rapide pour IFNB1 anticorps (Biotin) (ABIN2661188)

Antigène: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Reactivité: Souris

Hôte: Hamster

Clonalité: Monoclonal

Conjugué: Cet anticorp IFNB1 est conjugé à/à la Biotin

Application: Flow Cytometry (FACS)

Clone: MIB-5E9-1

Détail du produit anti-IFNB1 anticorps (Biotin)

Purification: The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur IFNB1

Antigène: IFNB1 (Interferon, beta 1, Fibroblast (IFNB1))

Autre désignation: IFN-beta

Sujet: Interferon-β is a member of the type I interferon class. Type I IFNs are involved in the innate immune system, being released non-specifically during the early stage of infection in response to stimuli such as viruses, dsRNA, LPS, and bacterial components. Once secreted by virus-infected or activated cells, they bind to the IFNα/β receptor (IFNAR), which is found on almost all cell types, and, via the JAK-STAT pathway, induce the expression of hundreds of IFN-stimulated genes (ISGs). While the function of many of these proteins remains to be elucidated, a hallmark of type I IFNs is their anti-viral activities, both general and specific against particular viruses. Type I IFNs also regulate cell growth and apoptosis, and exert various immunomodulatory and inflammatory effects. As such, they are also clinically relevant, both as therapeutics and as targets of inhibition for the treatment of various autoimmune diseases and cancer. Mouse IFN-β is a ~20 kD monomeric glycoprotein. It has 50 % amino acid sequence homology with mouse IFN-α, its closest related protein, and 62 % homology with human IFN-β. IFN-β is currently the therapeutic of choice for treating multiple sclerosis.

Pathways: Signalistation JAK/STAT, TCR Signaling, Signalisation TLR, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Autophagy, Inflammasome