CLEC9A anticorps (PE)

N° du produit ABIN2662627

Détail du produit anti-CLEC9A anticorps (PE)

Antigène: CLEC9A (C-Type Lectin Domain Family 9, Member A (CLEC9A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CLEC9A est conjugé à/à la PE

Application: Intracellular Flow Cytometry (ICFC)

Purification: The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.

Clone: 8F9

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Protect from prolonged exposure to light. Do not freeze.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CLEC9A

Antigène: CLEC9A (C-Type Lectin Domain Family 9, Member A (CLEC9A))

Autre désignation: CD370 (CLEC9A Produits)

Synonymes: anticorps 9830005G06Rik, anticorps DNGR-1, anticorps DNGR1, anticorps UNQ9341, anticorps RGD1562513, anticorps C-type lectin domain family 9, member a, anticorps C-type lectin domain containing 9A, anticorps C-type lectin domain family 9, member A, anticorps Clec9a, anticorps CLEC9A

Sujet: CD370 (CLEC9A), also known as DNGR1, is a type II transmembrane protein consisting of a single extracellular C-type lectin domain (CTLD) that is connected to the transmembrane domain by a stalk region, and an intracellular cytoplasmic tail with immunoreceptor tyrosine-based activation motif (ITAM). In humans, CLEC9A is strictly expressed on BDCA3-positive conventional dendritic cells (cDC) and CD16- monocytes. CLEC9A recognizes a ubiquitous preformed acid-labile protein associated ligand(s) that is exposed on necrotic cells. CLEC9A ligation is necessary for efficient cross-presentation of dead-cell-associated antigen by recruitment and activation of the tyrosine kinase Syk.