CLEC10A anticorps

N° du produit ABIN2664536

Détail du produit anti-CLEC10A anticorps

Antigène: CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CLEC10A est non-conjugé

Application: ELISA (Capture)

Purification: The antibody was purified by affinity chromatography.

Clone: H037G3

Isotype: IgG2a kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur CLEC10A

Antigène: CLEC10A (C-Type Lectin Domain Family 10, Member A (CLEC10A))

Autre désignation: CD301 (CLEC10A Produits)

Synonymes: anticorps CLEC10A, anticorps CD301, anticorps CLECSF13, anticorps CLECSF14, anticorps HML, anticorps HML2, anticorps MGL, anticorps CD301a, anticorps M-ASGP-BP-1, anticorps Mgl, anticorps Mgl1, anticorps Mgll, anticorps C-type lectin domain family 10 member A, anticorps C-type lectin domain containing 10A, anticorps C-type lectin domain family 10, member A, anticorps LOC607405, anticorps CLEC10A, anticorps Clec10a

Sujet: CD301, also known as CLEC10A, macrophage galactose/N-acetylgalactosamine (GalNAc) specific lectin (MGL), DCASGPR, and HML, is a 40 kD type II transmembrane glycoprotein, which belongs to the C-type lectin family. Human CD301 consists of a 39 amino acid (aa) cytoplasmic region, a 21 aa transmembrane segment, and a 256 aa extracellular domain (ECD) with one carbohydrate recognition domain (CRD) and a neck region. CD301 is expressed on immature myleloid dendritic cells and alternatively activated (tolerogenic) macrophages. The expression level is upregulated by immunosuppressant dexamethasone. Human CD301 has an exclusive specificity for rare terminal GalNAc structures, which are revealed on the tumor-associated mucin MUC1 and CD45 (RA, RB, and RC but not RO isoforms). This interaction inhibits effector T cell activation and induces their apoptosis. CD301 also binds the GP envelope glycoprotein on Marburg and Ebola viruses and enhances viral entry and infectivity.