DDX1 anticorps

N° du produit ABIN2664923

Détail du produit anti-DDX1 anticorps

Antigène: DDX1 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 (DDX1))

Reactivité: Humain, Souris

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DDX1 est non-conjugé

Application: Flow Cytometry (FACS)

Purification: The antibody was purified by affinity chromatography.

Clone: 9F12B04

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur DDX1

Antigène: DDX1 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 (DDX1))

Autre désignation: DDX1 (DDX1 Produits)

Synonymes: anticorps CG9054, anticorps DDX1, anticorps Dbp79E, anticorps DmDDX1, anticorps DmRH12, anticorps Dmel\\CG9054, anticorps anon-79E, anticorps DBP-RB, anticorps UKVH5d, anticorps si:ch211-214k9.2, anticorps si:dkey-161f12.1, anticorps AA409185, anticorps Dead-box-1, anticorps DEAD-box helicase 1, anticorps DEAD/H-box helicase 1 L homeolog, anticorps DEAD (Asp-Glu-Ala-Asp) box helicase 1, anticorps DEAD (Asp-Glu-Ala-Asp) box polypeptide 1, anticorps Ddx1, anticorps DDX1, anticorps ddx1.L, anticorps ddx1

Sujet: DDX1, also known as DEAD box protein retinoblastoma, is a member of the DEAD (Asp-Glu-Ala-Asp)-box RNA helicase family. DDX1 possesses RNA nuclease, binding, unwinding, and ATPase activities, and is thus involved in RNA metabolism, pre-mRNA splicing, translation initiation, and ribosome biogenesis. DDX1 interacts with the Rev protein of HIV-1 and has been shown to be crucial in the viral RNA replication. DDX1 was found to locate to the area of DNA damage induced by ionizing radiation and is implicated to participate in double-strand DNA break repair. DDX1 also acts as a transcriptional coactivator to facilitate NF-κB mediated gene activation. Elevated expression of DDX1 was observed in a number of tumors such as retinoblastoma, neuroblastoma, and testicular carcinoma. The accumulation of DDX1 is associated with cancer metastasis and poor survival.

Pathways: Ribonucleoprotein Complex Subunit Organization