FOXO1 anticorps

N° du produit ABIN2664978

Cet anticorps Souris Monoclonal détecte spécifiquement FOXO1 dans WB. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour FOXO1 anticorps (ABIN2664978)

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp FOXO1 est non-conjugé

Application: Western Blotting (WB)

Clone: 2F8B08

Détail du produit anti-FOXO1 anticorps

Purification: The antibody was purified by affinity chromatography.

Isotype: IgG1 kappa

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Concentration: 0.5 mg/mL

Buffer: Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Stockage commentaire: The antibody solution should be stored undiluted between 2°C and 8°C.

Détails sur FOXO1

Antigène: FOXO1 (Forkhead Box O1 (FOXO1))

Autre désignation: FOXO1

Sujet: FOXO1 is a transcription factor, belonging to the O subfamily of forkhead box-containing proteins. The forkhead proteins are substrates of Akt/PKB and glucocorticoid-induced kinases that mediate insulin signaling. FOXO1 binds to the conserved insulin-responsive elements and acts as a transcriptional activator. The FOXO1 target genes are involved in cell metabolism, growth, and differentiation. Upon insulin stimulation, FOXO1 proteins are phosphorylated by AKT/PKB through the PI3K pathway, resulting in the translocation of FOXO1 proteins from the nucleus to the cytoplasm. The expression of FOXO1 target genes are then inhibited by FOXO1. FOXO1 has been reported to regulate maturation and class-switch recombination of B cells, as well as participating in regulatory T cell function. FOXO1-deficient mice are embryonic lethal, suggesting that FOXO1 has crucial functions in development which cannot be compensated by other FoxO family members.

Pathways: Signalisation PI3K-Akt, Cycle Cellulaire, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Carbohydrate Metabolic Process, CXCR4-mediated Signaling Events, BCR Signaling