TCP1 alpha/CCTA anticorps

N° du produit ABIN2666194

Détail du produit anti-TCP1 alpha/CCTA anticorps

Antigène: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TCP1 alpha/CCTA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Réactivité croisée (Details): Recognizes ΔN-isoforms

Purification: The antibody was purified by antigen-affinity chromatography.

Clone: Poly6190

Isotype: IgG

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Upon receipt, store frozen at -20°C.

Détails sur TCP1 alpha/CCTA

Antigène: TCP1 alpha/CCTA (TCP1) (T-Complex 1 (TCP1))

Autre désignation: p63 (TCP1 Produits)

Synonymes: anticorps CCT-alpha, anticorps CCT1, anticorps CCTa, anticorps D6S230E, anticorps TCP-1-alpha, anticorps AI528772, anticorps CCT, anticorps Cct1, anticorps Ccta, anticorps TRic, anticorps Tcp-1, anticorps Tp63, anticorps c-cpn, anticorps p63, anticorps TRiC, anticorps CCTalpha, anticorps BEST:GH05123, anticorps CG5374, anticorps Dmel\\CG5374, anticorps T-cpl, anticorps TCP-1alpha, anticorps TCPA_DROME, anticorps Tcp1, anticorps Tcp1-alpha, anticorps gh05123, anticorps cct-alpha, anticorps ccta, anticorps tcp1, anticorps tcp1-a, anticorps tcp1a, anticorps tcp1alpha, anticorps CHUNP6875, anticorps fa13h08, anticorps wu:fa13h08, anticorps wu:fc95g06, anticorps t-complex 1, anticorps T-complex protein 1 subunit alpha, anticorps t-complex protein 1, anticorps Tcp1-like, anticorps t-complex 1 S homeolog, anticorps TCP1, anticorps cct-1, anticorps Tcp1, anticorps T-cp1, anticorps tcp1.S, anticorps tcp1

Sujet: P63 (ΔN) is a member of the p53 family. This protein has multiple isoforms TA p63-α, -β, γ, ΔN p63-α, -β, and -γ. The molecular weights of the p63 isoforms α=66 kD, β=52 kD, and γ=45 kD. This nuclear protein is essential for limb formation, epidermal morphogenesis, and epithelial stem cell regeneration. δN isoforms are antagonistic to p53, TA isoforms can transactivate p53 targets. The p63 ΔN isoforms repress TA isoforms, mutant p53 abrogates p63 transactivation. This protein interacts with p53, p73, and the various TA- and ΔN isoforms. The Poly6190 antibody recognizes human p63 ΔN isoforms and has been shown to be useful for Western blotting.