Nanog anticorps
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- Antigène Voir toutes Nanog (NANOG) Anticorps
- Nanog (NANOG) (Nanog Homeobox (NANOG))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Nanog est non-conjugé
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Application
- Biochemical Assay (BCA)
- Purification
- The antibody was purified by affinity chromatography.
- Clone
- 16H3A48
- Isotype
- IgG1 kappa
- Top Product
- Discover our top product NANOG Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Upon receipt, store undiluted at 4°C
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- Antigène
- Nanog (NANOG) (Nanog Homeobox (NANOG))
- Autre désignation
- Nanog (NANOG Produits)
- Synonymes
- anticorps 2410002E02Rik, anticorps ENK, anticorps ecat4, anticorps NANOG, anticorps hacp, anticorps wu:fd19e04, anticorps wu:fd20a07, anticorps zgc:193933, anticorps Nanog homeobox, anticorps nanog homeobox, anticorps Nanog, anticorps NANOG, anticorps nanog
- Sujet
- NANOG is a homeodomain-containing transcription factor that is essential for early embryonic development. It is primarily expressed in pluripotent embryonic stem (ES) cells and cancer cell lines, maintaining undifferentiated statuses of the cells and is downregulated upon differentiation. Si-RNA mediated knockdown of NANOG in ES cells induces lineage differentiation. Overexpression of NANOG allows for the leukemia inhibitory factor (LIF)-independent selfrenewal in undifferentiated ES cells. Nanog functionally works with OCT4 and SOX2 to support pluripotency and selfrenewal in ES cells and the expression of NANOG is regulated by OCT4/SOX2 heterodimers. Expression of NANOG has been detected in several types of tumor cells. The expression level of NANOG in cancer cells has been shown to be correlated with the malignancy of cancers.
- Pathways
- Stem Cell Maintenance
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