DC-SIGN/CD209 anticorps
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- Antigène Voir toutes DC-SIGN/CD209 (CD209) Anticorps
- DC-SIGN/CD209 (CD209) (CD209)
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp DC-SIGN/CD209 est non-conjugé
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Application
- Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Marque
- BD Pharmingen™
- Attributs du produit
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The DCN46 antibody specifically binds to dendritic cell-specific ICAM-3 grabbing nonintegrin (DC-SIGN or CD209), a type-II membrane protein of approximately 44 kDa with a mannose-binding C-type lectin domain. It is highly expressed on dendritic cells in mucosal tissues. Its sequence is identical to the HIV-1 envelope gp120-binding C-type lectin, and reports suggest that DC-SIGN binds to HIV-1 gp120 and effectively transmits infectious HIV-1 to resting T lymphocytes expressing CD4 and chemokine receptors. The C-type lectin domain of DC-SIGN is also capable of binding other pathogenic viruses, bacteria, and parasites. Reports also suggest that DC-SIGN enables the highly efficient migration of dendritic cells from blood into the tissues. It can interact with ICAM-2, which has a similar sequence as ICAM-3, and is abundantly expressed on vascular and lymphoid endothelium. Thus, DC-SIGN mediates dendritic cells rolling and transendothelial migration, and its interaction with ICAM-2 is essential to specific migratory functions of dendritic cells. Immunohistochemistry of dendritic cells stained for CD209 (DC-SIGN). An acetone-fixed frozen section from human tonsil was stained with the Purified Mouse Anti-Human CD209 antibody. Dendritic cells expressing CD209 (DC-SIGN) can be identified by the intense brown labeling of their cell membranes (magnification 40X).
BD Pharmingen™ Purified Mouse Anti-Human CD209 - Purified - Clone DCN46 - Isotype Mouse IgG2b, κ - Reactivity Hu - 1 mL - Purification
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogène
- Human Monocyte Derived DC Cells
- Clone
- DCN46
- Isotype
- IgG2b kappa
- Top Product
- Discover our top product CD209 Anticorps primaire
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- Indications d'application
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 31.25 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, goat serum, and ≤0.09 % sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C
- Stockage commentaire
- Store undiluted at 4°C.
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DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." dans: Cell, Vol. 100, Issue 5, pp. 587-97, (2000) (PubMed).
: "Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses." dans: Cell, Vol. 100, Issue 5, pp. 575-85, (2000) (PubMed).
: "DC-SIGN: a guide to some mysteries of dendritic cells." dans: Cell, Vol. 100, Issue 5, pp. 491-4, (2000) (PubMed).
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DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells." dans: Cell, Vol. 100, Issue 5, pp. 587-97, (2000) (PubMed).
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- Antigène
- DC-SIGN/CD209 (CD209) (CD209)
- Autre désignation
- CD209 (CD209 Produits)
- Synonymes
- anticorps CDSIGN, anticorps CLEC4L, anticorps DC-SIGN, anticorps DC-SIGN1, anticorps cd209, anticorps CLEC4M, anticorps si:ch211-224h1.3, anticorps CD209, anticorps CIRE, anticorps Dcsign, anticorps SIGN-R1, anticorps SIGNR5, anticorps Cd209, anticorps CD209 molecule, anticorps CD209a antigen, anticorps CD209 antigen-like protein D, anticorps CD209c molecule, anticorps CD209 antigen, anticorps CD209, anticorps cd209, anticorps Cd209a, anticorps LOC100529184, anticorps Cd209c, anticorps LOC100460708, anticorps LOC105484282
- Sujet
- Synonyms: DC-SIGN
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