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PARP1 anticorps (AA 215-525)
PARP1
Reactivité: Humain, Souris
WB, IHC, IP, ICC
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN2745551
Détail du produit anti-PARP1 anticorps
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Antigène
Voir toutes PARP1 Anticorps
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
Épitope
Tous les épitopes à travers PARP1 Anticorps.
AA 215-525
Reactivité
Toutes les réactivités sur PARP1 Anticorps
Humain, Souris
Hôte
Toutes les hôtes sur PARP1 Anticorps
Lapin
Clonalité
Toutes les clonalités sur PARP1 Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers PARP1 Anticorps
Cet anticorp PARP1 est non-conjugé
Application
Tous les applications à travers PARP1 Anticorps.
Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunocytochemistry (ICC)
Specificité
Recognizes mouse PARP-1.
Réactivité croisée
Humain, Souris
Réactivité croisée (Details)
Cross-reacts weakly with human PARP-1.
Immunogène
Recombinant mouse PARP-1 [ARTD1] (aa 215-525).
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Information d'application
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Indications d'application
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Stockage
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Format
Liquid
Concentration
Lot specific
Buffer
Contains 0.1 % sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 1 year after receipt when stored at -20°C.
Date de péremption
12 months
Détails sur PARP1
(cache)
Antigène
PARP1
(Poly (ADP-Ribose) Polymerase 1 (PARP1))
Autre désignation
PARP-1 [ARTD1] (PARP1 Produits )
Synonymes
anticorps ADPRT, anticorps ADPRT 1, anticorps ADPRT1, anticorps ARTD1, anticorps PARP, anticorps PARP-1, anticorps PPOL, anticorps pADPRT-1, anticorps Adprt, anticorps Parp-1, anticorps 5830444G22Rik, anticorps AI893648, anticorps Adprp, anticorps Adprt1, anticorps C80510, anticorps parp-1, anticorps sPARP-1, anticorps BEST:LD21673, anticorps CG17685, anticorps CG17696, anticorps CG17718, anticorps CG40411, anticorps D.PARP, anticorps Dm.pARTa, anticorps Dmel\\CG40411, anticorps LD21673.3prime, anticorps PARP1, anticorps dPARP, anticorps parp, anticorps adprt1, anticorps padprt-1, anticorps ppol, anticorps si:dkey-206f10.3, anticorps wu:fc60f12, anticorps zgc:110092, anticorps poly(ADP-ribose) polymerase 1, anticorps poly (ADP-ribose) polymerase 1, anticorps poly (ADP-ribose) polymerase family, member 1, anticorps Poly-(ADP-ribose) polymerase, anticorps poly(ADP-ribose) polymerase 1 L homeolog, anticorps PARP1, anticorps Parp1, anticorps Parp, anticorps parp1.L, anticorps parp1
Sujet
PARP-1 (ARTD1) is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. PARP-1 positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. It forms a complex with EEF1A1 and TXK that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
UniProt
P11103
Pathways
Apoptose , Caspase Cascade in Apoptosis , Réparation de l'ADN , Production of Molecular Mediator of Immune Response , Maintenance of Protein Location
Vus récemment
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