Fusion Glycoprotein F0 (AA 136-608) anticorps (HRP)

N° du produit ABIN2754555

Détail du produit

Antigène: Fusion Glycoprotein F0

Épitope: AA 136-608

Reactivité: Canine Distemper Virus (CDV)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: HRP

Application: ELISA, Western Blotting (WB)

Purification: Caprylic Acid Ammonium Sulfate Precipitation

Immunogène: Recombinant Canine distemper virus Fusion glycoprotein F0 protein(136-608aa)

Isotype: IgG

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Agent conservateur: ProClin

Précaution d'utilisation: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C/-20 °C/-80 °C

Détail du antigène

Antigène: Fusion Glycoprotein F0

Classe de substances: Viral Protein

Sujet: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.

UniProt: P12569