SPHK1 anticorps (pSer225)

N° du produit ABIN2764174

Cet anticorps Lapin Polyclonal détecte spécifiquement SPHK1 dans WB et ELISA. Il présente une réactivité envers Souris.

Aperçu rapide pour SPHK1 anticorps (pSer225) (ABIN2764174)

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SPHK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Détail du produit anti-SPHK1 anticorps

Épitope: pSer225

Réactivité croisée: Souris

Attributs du produit: Activation of Sphingosine kinase (Sphk) increases the bioactive lipid, sphingosine 1-phosphate (S1P) and has been observed in a variety of cancer cells. Phosphorylation of sphingosine by sphingosine kinase (Sphk) is the rate-limiting step in the cellular synthesis of S1P. A principle activation event is the phosphorylation of serine 225 of sphiongosine kinase 1. Inhibition of Sphk1 phosphorylation and hence, Sphk activity is an important target for the development of drugs for cancer, inflammation, cardioprotection as well as a many other indications.

Purification: Antigen Immunoaffiinity Purification

Immunogène: Rabbits were immunized with a synthetic peptide incorporating the serine 225 phosphorylation site of mouse sphingosie kinase 1

Isotype: IgG

Information d'application

Indications d'application: Antibody can be used for Western blotting (1-5 μg/mL). Antibody shows some cross reactivity (~10 % by ELISA) with other phosphoserine containing proteins. Optimal concentration should be evaluated by serial dilutions.

Restrictions: For Research Use only

Stockage

Concentration: Lot specific

Buffer: Provided as solution in phosphate buffered saline with 0.08 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Détails sur SPHK1

Antigène: SPHK1 (Sphingosine Kinase 1 (SPHK1))

Autre désignation: Sphingosine Kinase 1

UniProt: Q8CI15

Pathways: VEGF Signaling