Mre11 anticorps (N-Term)

N° du produit ABIN2774155

L’anticorps anti-Mre11 Polyclonal Lapin est utilisé pour la détection de Mre11 dans des échantillons de Humain, Rat, Souris, Chien, Lapin, Saccharomyces cerevisiae, Cobaye, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio) et Chévre. Il a été validé pour WB.

Aperçu rapide pour Mre11 anticorps (N-Term) (ABIN2774155)

Antigène: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Reactivité: Humain, Rat, Souris, Chien, Lapin, Saccharomyces cerevisiae, Cobaye, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio), Chévre

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Mre11 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-Mre11 anticorps

Épitope: N-Term

Séquence: DTFVTLDEIL RLAQENEVDF ILLGGDLFHE NKPSRKTLHT CLELLRKYCM

Homologie: Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against MRE11A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human MRE11A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 708 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Mre11

Antigène: Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))

Autre désignation: MRE11A

Sujet: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Alias Symbols: ATLD, HNGS1, MRE11, MRE11B
Protein Interaction Partner: HUWE1, CIAO1, ATRX, BRCA1, RPA3, RPA2, RPA1, EED, ABCF1, C14orf166, RTCB, RPL26L1, NELFB, IGF2BP3, LRRFIP1, MAP7, EIF2B2, EIF2B3, YBX3, RPL27, RFC4, QARS, NMT1, HNRNPM, ILF2, HNRNPU, HNRNPA2B1, FLII, DHX9, DDX1, LMNA, PAN2, UBC, MCM2, GINS1, MDC1, RNF8, C
Protein Size: 708

Poids moléculaire: 80 kDa

ID gène: 4361

NCBI Accession: NM_005591, NP_005582

UniProt: P49959

Pathways: Réparation de l'ADN