Mre11 anticorps (N-Term)
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- Antigène Voir toutes Mre11 (MRE11A) Anticorps
- Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
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Épitope
- N-Term
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Reactivité
- Humain, Rat, Souris, Chien, Lapin, Saccharomyces cerevisiae, Cobaye, Boeuf (Vache), Cheval, Poisson zèbre (Danio rerio), Chévre
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp Mre11 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- DTFVTLDEIL RLAQENEVDF ILLGGDLFHE NKPSRKTLHT CLELLRKYCM
- Homologie
- Cow: 100%, Dog: 100%, Goat: 93%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Yeast: 100%, Zebrafish: 93%
- Attributs du produit
- This is a rabbit polyclonal antibody against MRE11A. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human MRE11A
- Top Product
- Discover our top product MRE11A Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 708 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- Mre11 (MRE11A) (MRE11 Meiotic Recombination 11 Homolog A (S. Cerevisiae) (MRE11A))
- Autre désignation
- MRE11A (MRE11A Produits)
- Synonymes
- anticorps wu:faa63d12, anticorps zgc:64018, anticorps Mre11, anticorps Mre11b, anticorps ATLD, anticorps HNGS1, anticorps MRE11, anticorps MRE11B, anticorps MRE11 homolog A, double strand break repair nuclease, anticorps MRE11 homolog, double strand break repair nuclease, anticorps MRE11A homolog A, double strand break repair nuclease, anticorps mre11a, anticorps MRE11, anticorps Mre11a
- Sujet
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This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog, this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
Alias Symbols: ATLD, HNGS1, MRE11, MRE11B
Protein Interaction Partner: HUWE1, CIAO1, ATRX, BRCA1, RPA3, RPA2, RPA1, EED, ABCF1, C14orf166, RTCB, RPL26L1, NELFB, IGF2BP3, LRRFIP1, MAP7, EIF2B2, EIF2B3, YBX3, RPL27, RFC4, QARS, NMT1, HNRNPM, ILF2, HNRNPU, HNRNPA2B1, FLII, DHX9, DDX1, LMNA, PAN2, UBC, MCM2, GINS1, MDC1, RNF8, C
Protein Size: 708 - Poids moléculaire
- 80 kDa
- ID gène
- 4361
- NCBI Accession
- NM_005591, NP_005582
- UniProt
- P49959
- Pathways
- Réparation de l'ADN
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