5HT1B Receptor anticorps (N-Term)
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- Antigène Voir toutes 5HT1B Receptor (HTR1B) Anticorps
- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
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Épitope
- N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp 5HT1B Receptor est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- MEEPGAQCAP PPPAGSETWV PQANLSSAPS QNCSAKDYIY QDSISLPWKV
- Homologie
- Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against HTR1B. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the N terminal region of human HTR1B
- Top Product
- Discover our top product HTR1B Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 390 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- 5HT1B Receptor (HTR1B) (Serotonin Receptor 1B (HTR1B))
- Autre désignation
- HTR1B (HTR1B Produits)
- Synonymes
- anticorps 5-HT1B, anticorps 5-HT1DB, anticorps HTR1D2, anticorps HTR1DB, anticorps S12, anticorps 5-HT1Db, anticorps 5-HT1-LIKE, anticorps HTR1B, anticorps 5-HT-dro2B, anticorps 5-HT1BDro, anticorps 5-HT[1B]Dro, anticorps 5-HT[[1BDro]], anticorps 5-HT[[1B]], anticorps 5-HT[[1B]]DRO, anticorps 5-HT[[1B]]Dro, anticorps 5-HT[[dro2B]], anticorps 5HT-R2B, anticorps 5HT-dro2B, anticorps 5HT-dro[[2B]], anticorps 5HT1B, anticorps 5htdro2b, anticorps CG15113, anticorps CG30126, anticorps DRO2B, anticorps Dm5HTdro2B, anticorps Dmel\\CG15113, anticorps Dmel_CG30126, anticorps d5-HT1B, anticorps 5-HT-1B, anticorps zgc:194666, anticorps zgc:194690, anticorps 5-hydroxytryptamine receptor 1B, anticorps 5-hydroxytryptamine (serotonin) receptor 1B, anticorps HTR1B, anticorps Htr1b, anticorps 5-HT1B, anticorps htr1b
- Sujet
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The pathophysiology of depression remains enigmatic, although abnormalities that involve serotonin signaling have been implicated. The serotonin 1B receptor [5-hydroxytryptamine (5-HT1B) receptor] interacts with p11. p11 increases localization of 5-HT1B receptors at the cell surface. p11 is increased in rodent brains by antidepressants or electroconvulsive therapy, but decreased in an animal model of depression and in brain tissue from depressed patients. Overexpression of p11 increases 5-HT1B receptor function in cells and recapitulates certain behaviors seen after antidepressant treatment in mice. p11 knockout mice exhibit a depression-like phenotype and have reduced responsiveness to 5-HT1B receptor agonists and reduced behavioral reactions to an antidepressant.
Alias Symbols: S12, 5-HT1B, HTR1D2, HTR1DB, 5-HT1DB
Protein Interaction Partner: MDFI, HTR1D, HTR1B, HTR1A, GSTK1, NME2,
Protein Size: 390 - Poids moléculaire
- 44 kDa
- ID gène
- 3351
- NCBI Accession
- NM_000863, NP_000854
- UniProt
- P28222
- Pathways
- Signalistation JAK/STAT, cAMP Metabolic Process, Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, S100 Proteins
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