RAD18 anticorps (Middle Region)

N° du produit ABIN2774766

Détail du produit anti-RAD18 anticorps

Antigène: RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Lapin, Boeuf (Vache), Chien, Cheval, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RAD18 est non-conjugé

Application: Western Blotting (WB)

Séquence: LSDRDLKKKL KEHGLSIQGN KQQLIKRHQE FVHMYNAQCD ALHPKSAAEI

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%

Attributs du produit: This is a rabbit polyclonal antibody against RAD18. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human RAD18

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 495 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur RAD18

Antigène: RAD18 (E3 ubiquitin-protein ligase RAD18 (RAD18))

Autre désignation: RAD18 (RAD18 Produits)

Synonymes: anticorps RNF73, anticorps 2810024C04Rik, anticorps Rad18sc, anticorps zgc:55577, anticorps RAD18, anticorps DDBDRAFT_0218120, anticorps DDBDRAFT_0304878, anticorps DDB_0218120, anticorps DDB_0304878, anticorps DKFZp469H0810, anticorps RAD18, E3 ubiquitin protein ligase, anticorps RAD18 E3 ubiquitin protein ligase, anticorps E3 ubiquitin-protein ligase RAD18, anticorps E3 ubiquitin-protein ligase, anticorps DNA repair protein and ATPase, anticorps C3HC4-type zinc finger-containing protein, anticorps RAD18, anticorps Rad18, anticorps rad18

Sujet: RAD18 is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, RAD18 is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.
Alias Symbols: RNF73
Protein Interaction Partner: TAX1BP1, UBC, SHPRH, RAD18, SIVA1, USP2, UBE2B, UBE2A, HLTF, PCNA, BPLF1, USP5, DBF4, BRCA1, DZIP3, POLH, DTL, Ankrd32, MLKL, ECT2, RPL10A, TRIM23, PCGF6, TRIM8, RFC2, CPD, SPRTN, ZMYM2, MAPK8, POLN, WRNIP1, gag-pol, ORC2, SUMO2, POLK, NBN, Smc6, HIST1H2A
Protein Size: 495

Poids moléculaire: 56 kDa

ID gène: 56852

NCBI Accession: NM_020165, NP_064550

UniProt: Q9NS91