UBE2L3 anticorps (C-Term)
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- Antigène Voir toutes UBE2L3 Anticorps
- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
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Épitope
- C-Term
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Reactivité
- Humain, Souris, Rat, Chien, Boeuf (Vache), Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp UBE2L3 est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Séquence
- TDQVIQSLIA LVNDPQPEHP LRADLAEEYS KDRKKFCKNA EEFTKKYGEK
- Homologie
- Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against UBE2L3. It was validated on Western Blot and immunohistochemistry.
- Purification
- Protein A purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C terminal region of human UBE2L3
- Top Product
- Discover our top product UBE2L3 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 668 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
- Autre désignation
- UBE2L3 (UBE2L3 Produits)
- Synonymes
- anticorps E2-F1, anticorps L-UBC, anticorps UBCH7, anticorps UbcM4, anticorps C79827, anticorps Ubce7, anticorps ube2l3, anticorps wu:fc22h11, anticorps zgc:86727, anticorps UBE2L3, anticorps ube2l3l, anticorps wu:fb38h03, anticorps ubiquitin conjugating enzyme E2 L3, anticorps ubiquitin-conjugating enzyme E2L 3, anticorps ubiquitin-conjugating enzyme E2L 3a, anticorps ubiquitin conjugating enzyme E2 L3 S homeolog, anticorps ubiquitin-conjugating enzyme E2L 3b, anticorps UBE2L3, anticorps Ube2l3, anticorps ube2l3a, anticorps ube2l3.S, anticorps ube2l3b
- Sujet
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). UBE2L3 is a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro.This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. It shows a very broad expression pattern and is strongly expressed in many tissues. It may represent one member of a small gene family that encode different but related proteins involved either directly or indirectly in transcriptional regulation. Their indirect effects on transcriptional regulation may include chromatin remodeling. It is closely related to another member of this family, a protein that has been correlated with the metastatic potential of certain carcinomas. These two proteins are so closely related that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. One of the proteins known to be a target protein for this gene product is p53. Deacteylation of p53 is correlated with a loss of growth inhibition in transformed cells supporting a connection between these gene family members and metastasis.
Alias Symbols: E2-F1, L-UBC, UBCH7, UbcM4
Protein Interaction Partner: UBC, TRAF6, NEDD4, ITCH, MUL1, SMURF2, SMURF1, WWP2, WWP1, ARIH2, RNF144A, UBA1, PARK2, RNF144B, HACE1, ARIH1, UBE3A, UBE2L3, UBA6, UBR5, CACNA1B, MAP1LC3B, BAG3, HSPA4, AICDA, CCNB1IP1, FN1, RBX1, LIG4, ZPR1, USP9X, SF1, VDAC2, UCHL3, UBE2V2, UBE2D2, UBE
Protein Size: 668 - Poids moléculaire
- 75 kDa
- ID gène
- 7332
- NCBI Accession
- NM_004739, NP_003338
- UniProt
- P68036
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