KCNQ4 anticorps (Middle Region)
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- Antigène Voir toutes KCNQ4 Anticorps
- KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))
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Épitope
- Middle Region
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Reactivité
- Humain, Souris, Rat, Lapin, Boeuf (Vache), Chien, Cobaye, Cheval, Porc
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KCNQ4 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- SSRMGIKDRI RMGSSQRRTG PSKQHLAPPT MPTSPSSEQV GEATSPTKVQ
- Homologie
- Cow: 93%, Dog: 92%, Guinea Pig: 92%, Horse: 93%, Human: 100%, Mouse: 100%, Pig: 93%, Rabbit: 100%, Rat: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against KCNQ4. It was validated on Western Blot using a cell lysate as a positive control.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the middle region of human KCNQ4
- Top Product
- Discover our top product KCNQ4 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 695 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- KCNQ4 (Potassium Voltage-Gated Channel, KQT-Like Subfamily, Member 4 (KCNQ4))
- Autre désignation
- KCNQ4 (KCNQ4 Produits)
- Synonymes
- anticorps KCNQ4, anticorps k(v)7.4, anticorps kv7.4, anticorps DFNA2, anticorps DFNA2A, anticorps KV7.4, anticorps potassium voltage-gated channel subfamily Q member 4, anticorps potassium channel, voltage gated KQT-like subfamily Q, member 4, anticorps potassium voltage-gated channel, subfamily Q, member 4, anticorps KCNQ4, anticorps kcnq4, anticorps Kcnq4
- Sujet
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The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: DFNA2, KV7.4, DFNA2A
Protein Interaction Partner: STIP1, STUB1, HSP90B1, HSP90AA1, HSPA8, DNAJA1, KCNQ3,
Protein Size: 695 - Poids moléculaire
- 77 kDa
- ID gène
- 9132
- NCBI Accession
- NM_004700, NP_004691
- UniProt
- P56696
- Pathways
- Sensory Perception of Sound
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