TRPM8 anticorps (N-Term)

N° du produit ABIN2776255

Détail du produit anti-TRPM8 anticorps

Antigène: TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))

Épitope: N-Term

Reactivité: Humain, Rat, Souris, Cobaye, Lapin, Chien, Cheval, Porc, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRPM8 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: YILDNNHTHL LLVDNGCHGH PTVEAKLRNQ LEKYISERTI QDSNYGGKIP

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against TRPM8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human TRPM8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1104 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TRPM8

Antigène: TRPM8 (Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))

Autre désignation: TRPM8 (TRPM8 Produits)

Synonymes: anticorps TRPM8, anticorps trpp8, anticorps ltrpc6, anticorps trpm8b, anticorps LTRPC6, anticorps TRPP8, anticorps CMR1, anticorps LTrpC-6, anticorps Trp-p8, anticorps transient receptor potential cation channel subfamily M member 8, anticorps transient receptor potential cation channel subfamily M member 8b L homeolog, anticorps transient receptor potential cation channel, subfamily M, member 8, anticorps TRPM8, anticorps trpm8b.L, anticorps Trpm8

Sujet: TRPM8 is the receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. TRPM8 is activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH . TRPM8 is involved in menthol sensation. TRPM8 is permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. TRPM8 was activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
Alias Symbols: LTRPC6, MGC2849, TRPP8
Protein Interaction Partner: CHAMP1, TXLNA, ZC3H18, RTF1, SF3A3, USP10,
Protein Size: 1104

Poids moléculaire: 128 kDa

ID gène: 79054

NCBI Accession: NM_024080, NP_076985

UniProt: Q7Z2W7