TRPM8 Produits
(Transient Receptor Potential Cation Channel, Subfamily M, Member 8 (TRPM8))
Catégories
Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.
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Catégories TRPM8 en vedette
TRPM8 Anticorps
High quality antibodies with extensive validation data.
TRPM8 Kits ELISA
Reliable ELISA kits for a wide range of species.
TRPM8 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
TRPM8 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (5)
N° du produit
ABIN392821
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (5)
N° du produit
ABIN3029240
Quantité
0.4 mL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (5)
N° du produit
ABIN3029242
Quantité
0.4 mL
Fiche technique
Fiche technique
TRPM8 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6960128
Quantité
96 tests
Fiche technique
Fiche technique
TRPM8 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN3096054
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN3126784
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Insect Cells
Validations
- (1)
N° du produit
ABIN3096055
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits TRPM8
: "TRPM8 thermosensation in poikilotherms mediates both skin colour and locomotor performance responses to cold temperature." dans: Communications biology, Vol. 6, Issue 1, pp. 127, (2023) (PubMed).: "TRPM8-Rap1A Interaction Sites as Critical Determinants for Adhesion and Migration of Prostate and Other Epithelial Cancer Cells." dans: Cancers, Vol. 14, Issue 9, (2022) (PubMed).
: "Gpr83 Tunes Nociceptor Function, Controlling Pain." dans: Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, (2022) (PubMed).
: "TRPM8 as an Anti-Tumoral Target in Prostate Cancer Growth and Metastasis Dissemination." dans: International journal of molecular sciences, Vol. 23, Issue 12, (2022) (PubMed).
: "Testosterone-androgen receptor: The steroid link inhibiting TRPM8-mediated cold sensitivity." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 34, Issue 6, pp. 7483-7499, (2021) (PubMed).
: "TRPM8-androgen receptor association within lipid rafts promotes prostate cancer cell migration." dans: Cell death & disease, Vol. 10, Issue 9, pp. 652, (2020) (PubMed).
: "Activation of Transient Receptor Potential Melastatin Subtype 8 Attenuates Cold-Induced Hypertension Through Ameliorating Vascular Mitochondrial Dysfunction." dans: Journal of the American Heart Association, Vol. 6, Issue 8, (2018) (PubMed).
: "TRPM8 in the negative regulation of TNFα expression during cold stress." dans: Scientific reports, Vol. 7, pp. 45155, (2017) (PubMed).
: "TRPM8 inhibits endothelial cell migration via a non-channel function by trapping the small GTPase Rap1." dans: The Journal of cell biology, Vol. 216, Issue 7, pp. 2107-2130, (2017) (PubMed).
: "Antibodies to the extracellular pore loop of TRPM8 act as antagonists of channel activation." dans: PLoS ONE, Vol. 9, Issue 9, pp. e107151, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à TRPM8
transient receptor potential cation channel subfamily M member 8 (TRPM8), transient receptor potential cation channel subfamily M member 8b L homeolog (trpm8b.L), transient receptor potential cation channel subfamily M member 8 (Trpm8), transient receptor potential cation channel, subfamily M, member 8 (Trpm8), transient receptor potential cation channel, subfamily M, member 8 (TRPM8), CMR1, LTrpC-6, ltrpc6, LTRPC6, Trp-p8, TRPM8, trpm8b, trpp8, TRPP8Protein level used designations for TRPM8
- transient receptor potential cation channel, subfamily M, member 8
- transient receptor potential cation channel subfamily M member 8b
- transient receptor potential cation channel subfamily M member 8
- transient potential cation channel subfamily M member 8
- LTrpC-6
- long transient receptor potential channel 6
- short form of the TRPM8 cationic channel
- transient receptor potential p8
- transient receptor potential subfamily M member 8
- trp-p8
- TRP ion channel TRPM8
- transient receptor potential-p8
- cold menthol receptor 1
- cold/menthol receptor 1
- menthol receptor
- transient receptor potential M8 protein
- transient receptor potential cation channel, subfamily M, member 8 (predicted), 3 prime
- transient receptor potential cation channel, subfamily M, member 8 (predicted), 5 prime
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