RUNX1T1 anticorps (Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related)) (Middle Region)

Details for Product anti-RUNX1T1 Antibody No. ABIN2778221
Antigène
  • MTG8
  • si:ch211-232j17.1
  • wu:fi14b07
  • zgc:154044
  • AML1T1
  • CBFA2T1
  • CDR
  • ETO
  • ZMYND2
  • Cbfa2t1h
  • Cbfa2t1
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
  • RUNX1 translocation partner 1 L homeolog
  • RUNX1 translocation partner 1
  • runx1t1
  • runx1t1.L
  • RUNX1T1
  • Runx1t1
Épitope
Middle Region
8
7
3
2
2
1
1
1
1
1
Reactivité
Boeuf (Vache), Chien, Cobaye, Cheval, Humain, Souris, Lapin, Rat (Rattus), Poisson zèbre (Danio rerio)
53
27
14
7
6
5
4
4
4
3
3
3
2
1
Hôte
Lapin
46
7
Clonalité
Polyclonal
Conjugué
Cet anticorp RUNX1T1 est non-conjugé
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
32
26
11
5
4
1
1
1
1
Options
Immunogène The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1
Séquence LHSEHPSKRP CTISPGQRYS PNNGLSYQPN GLPHPTPPPP QHYRLDDMAI
Homologie Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
Attributs du produit This is a rabbit polyclonal antibody against RUNX1T1. It was validated on Western Blot using a cell lysate as a positive control.
Purification Protein A purified
Plasmids, Primers & others Plasmids, Primers & others RUNX1T1 products on genomics-online (e.g. as negative or positive controls)
Antigène
Autre désignation RUNX1T1 (RUNX1T1 Antibody Extrait)
Sujet RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8,21)(q22,q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.
Alias Symbols: CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1
Protein Interaction Partner: EPS8, NECAB2, ABI3, GSE1, MID2, SPRY2, HOMER3, LPXN, ZMYM4, STX11, MEOX2, CCDC36, TRIM42, SPERT, CREB3L1, LZTS2, EFHC2, CPSF7, C19orf57, PRDM14, CBFA2T2, NCOR1, UBQLN4, ATN1, BCL6, ETS1, RUNX1, DNMT1, SPEN, RBPJ, UBE2E2, UBC, TRIM33, HDAC1, NCOR2, SIN3A,
Protein Size: 604
Poids moléculaire 68 kDa
ID gène 862
NCBI Accession NM_175636, NP_783554
UniProt Q06455
Indications d'application Optimal working dilutions should be determined experimentally by the investigator.
Commentaires

Antigen size: 567 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Agent conservateur Sodium azide
Précaution d'utilisation This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Conseil sur la manipulation Avoid repeated freeze-thaw cycles.
Stock -20 °C
Stockage commentaire For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Images (Fournisseur)
Western Blotting (WB) image for anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Middle Region) antibody (ABIN2778221) WB Suggested Anti-RUNX1T1 Antibody Titration: 1.25ug/ml Positive Control: HepG2 ce...
Western Blotting (WB) image for anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) (Middle Region) antibody (ABIN2778221) Host: Rabbit Target Name: WT1 Sample Type: 721_B Antibody Dilution: 1.0ug/ml ...
Background publications Lausen, Cho, Liu, Werner: "The nuclear receptor co-repressor (N-CoR) utilizes repression domains I and III for interaction and co-repression with ETO." dans: The Journal of biological chemistry, Vol. 279, Issue 47, pp. 49281-8, 2004 (PubMed).

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