SYNCRIP anticorps (Middle Region)

N° du produit ABIN2778979

Détail du produit anti-SYNCRIP anticorps

Antigène: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Boeuf (Vache), Lapin, Poisson zèbre (Danio rerio), Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SYNCRIP est non-conjugé

Application: Western Blotting (WB)

Séquence: IEIVFAKPPD QKRKERKAQR QAAKNQMYDD YYYYGPPHMP PPTRGRGRGG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against SYNCRIP. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Protein A purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human SYNCRIP

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 623 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SYNCRIP (ABIN2778979)

Ting, Wen, Liu, Hsieh-Li, Li, Lin-Chao: "The spinal muscular atrophy disease protein SMN is linked to the Golgi network." dans: PLoS ONE, Vol. 7, Issue 12, pp. e51826, (2013) (PubMed).

Groen, Fumoto, Blokhuis, Engelen-Lee, Zhou, van den Heuvel, Koppers, van Diggelen, van Heest, Demmers, Kirby, Shaw, Aronica, Spliet, Veldink, van den Berg, Pasterkamp: "ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN." dans: Human molecular genetics, Vol. 22, Issue 18, pp. 3690-704, (2013) (PubMed).

Détails sur SYNCRIP

Antigène: SYNCRIP (Synaptotagmin Binding, Cytoplasmic RNA Interacting Protein (SYNCRIP))

Autre désignation: SYNCRIP (SYNCRIP Produits)

Synonymes: anticorps GRY-RBP, anticorps GRYRBP, anticorps HNRNPQ, anticorps HNRPQ1, anticorps NSAP1, anticorps PP68, anticorps hnRNP-Q, anticorps 2610109K23Rik, anticorps 4632417O19Rik, anticorps Nsap1, anticorps Nsap1l, anticorps pp68, anticorps nsap1, anticorps wu:fe02c03, anticorps wu:fe47h09, anticorps SYNCRIP, anticorps hnrpq1, anticorps gry-rbp, anticorps rp1-3j17.2, anticorps synaptotagmin binding cytoplasmic RNA interacting protein, anticorps synaptotagmin binding, cytoplasmic RNA interacting protein, anticorps synaptotagmin binding cytoplasmic RNA interacting protein S homeolog, anticorps SYNCRIP, anticorps Syncrip, anticorps syncrip, anticorps syncrip.S

Sujet: Heterogenous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. SYNCRIP may be involved in translationally coupled mRNA turnover. It implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. It interacts in vitro preferentially with poly(A) and poly(U) RNA sequences.
Alias Symbols: GRY-RBP, NSAP1, RP1-3J17.2, dJ3J17.2, pp68, PP68, GRYRBP, HNRPQ1, hnRNP-Q
Protein Interaction Partner: FUS, PRMT8, UBC, SPRTN, SUMO2, SUMO3, STAU1, MDM2, RPA3, RPA2, RPA1, RNF2, EED, rev, GNB2L1, IQGAP1, RPS21, RPL24, RPL23A, PSMD7, RPSA, IARS, PRMT1, HNRNPU, FKBP3, MAP1S, C14orf166, RPS27L, NELFB, PARK2, FBXO6, TARDBP, CSF2, CD81, IGSF8, HMGA2, ICAM1, HMG
Protein Size: 623

Poids moléculaire: 69 kDa

ID gène: 10492

NCBI Accession: NM_006372, NP_006363

UniProt: O60506