p21 anticorps (N-Term)

N° du produit ABIN2779298

Cet anticorps anti-p21 est un anticorps Lapin Polyclonal détectant p21 dans IHC. Adapté pour Humain, Souris, Rat, Mouton, Boeuf (Vache), Chien, Lapin, Porc, Cobaye et Cheval.

Aperçu rapide pour p21 anticorps (N-Term) (ABIN2779298)

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Reactivité: Humain, Souris, Rat, Mouton, Boeuf (Vache), Chien, Lapin, Porc, Cobaye, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp p21 est non-conjugé

Application: Immunohistochemistry (IHC)

Détail du produit anti-p21 anticorps

Épitope: N-Term

Séquence: KACRRLFGPV DSEQLSRDCD ALMAGCIQEA RERWNFDFVT ETPLEGDFAW

Homologie: Cow: 100%, Dog: 92%, Guinea Pig: 92%, Horse: 83%, Human: 100%, Mouse: 92%, Pig: 100%, Rabbit: 92%, Rat: 100%, Sheep: 100%

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human CDKN1A

Information d'application

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur p21

Antigène: p21 (CDKN1A) (Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1) (CDKN1A))

Autre désignation: CDKN1A

Sujet: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.
Alias Symbols: CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Protein Interaction Partner: CCND1, PCNA, KRT31, TRIM54, TEX11, IKZF3, UBC, TRAF1, TCF4, SKP2, CCND3, CCND2, PHKG2, PHKA1, NCL, HSPA9, HSPA8, HSPA5, HSPA2, HSPA1A, HNRNPA2B1, CDK2, CDK5, CDK4, CDK3, CDC20, CCNE1, CCNB1, CCNA2, CAMK2D, ABR, GIGYF2, ANKRD17, UBR4, SNRNP200, FBXO21, PUF
Protein Size: 164

Poids moléculaire: 18 kDa

ID gène: 1026

NCBI Accession: NM_078467, NP_510867

UniProt: Q6FI05

Pathways: Signalisation p53, Signalisation PI3K-Akt, Cycle Cellulaire, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Hepatitis C, Synthesis of DNA, Autophagy