ZFPM1 anticorps (Middle Region)

N° du produit ABIN2779499

Détail du produit anti-ZFPM1 anticorps

Antigène: ZFPM1 (Zinc Finger Protein, Multitype 1 (ZFPM1))

Épitope: Middle Region

Reactivité: Humain, Rat, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZFPM1 est non-conjugé

Application: Western Blotting (WB)

Séquence: PPPPPPGHAP APESPRPGSG SGSGPGLAPA RSPGPAADGP IDLSKKPRRP

Homologie: Cow: 91%, Human: 100%, Rat: 83%

Attributs du produit: This is a rabbit polyclonal antibody against ZFPM1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ZFPM1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1006 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ZFPM1 (ABIN2779499)

Sugiyama, Tanaka, Kitajima, Zheng, Yen, Murotani, Yamatodani, Nakano: "Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation." dans: Blood, Vol. 111, Issue 4, pp. 1924-32, (2008) (PubMed).

Détails sur ZFPM1

Antigène: ZFPM1 (Zinc Finger Protein, Multitype 1 (ZFPM1))

Autre désignation: ZFPM1 (ZFPM1 Produits)

Synonymes: anticorps FOG, anticorps FOG1, anticorps ZC2HC11A, anticorps ZNF408, anticorps ZNF89A, anticorps Fog1, anticorps Xfog, anticorps fog, anticorps fog-1, anticorps fog1, anticorps FOG-1, anticorps si:dkey-20g6.1, anticorps si:dkey-38l12.1, anticorps ZNF469, anticorps ZFPM1, anticorps zinc finger protein, FOG family member 1, anticorps zinc finger protein, multitype 1, anticorps zinc finger protein, FOG family member 1 L homeolog, anticorps ZFPM1, anticorps Zfpm1, anticorps zfpm1.L, anticorps zfpm1

Sujet: ZFPM1 is a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM1 is an essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA1, GATA2 and GATA3. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. The heterodimer formed with GATA proteins is essential to activate expression of genes such as NFE2, ITGA2B, alpha- and beta-globin, while it represses expression of KLF1. ZFPM1 may be involved in regulation of some genes in gonads. ZFPM1 may also be involved in cardiac development, in a non-redundant way with ZFPM2/FOG2.
Alias Symbols: FOG, FOG1, ZNF408, ZNF89A
Protein Interaction Partner: GSK3B, CTBP2, TRIM21, MTA1, RBBP4, Rb1, GATA1, GIPC1, TOP3B, GATA2,
Protein Size: 1006

Poids moléculaire: 105 kDa

ID gène: 161882

NCBI Accession: NM_153813, NP_722520

UniProt: Q8IX07