ATF4 anticorps (N-Term)

N° du produit ABIN2779918

Cet anticorps Lapin Polyclonal détecte spécifiquement ATF4 dans WB et IHC. Il présente une réactivité avec des échantillons de Souris. Il a été cité dans 4+ publications.

Aperçu rapide pour ATF4 anticorps (N-Term) (ABIN2779918)

Antigène: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATF4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-ATF4 anticorps

Épitope: N-Term

Fonction: ATF4 Antibody - N-terminal region

Séquence: MALFTKSSSS VAVTDKDTFE LSTFLESSKA PQHDRDELPE QRSVGGGLDD

Homologie: Mouse: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ATF4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of mouse ATF4

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37017-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ATF4 (ABIN2779918)

Ye, Zhang, Ancrum, Manevich, Townsend, Tew: "Glutathione S-Transferase P-Mediated Protein S-Glutathionylation of Resident Endoplasmic Reticulum Proteins Influences Sensitivity to Drug-Induced Unfolded Protein Response." dans: Antioxidants & redox signaling, (2016) (PubMed).

Schneeberger, Dietrich, Sebastián, Imbernón, Castaño, Garcia, Esteban, Gonzalez-Franquesa, Rodríguez, Bortolozzi, Garcia-Roves, Gomis, Nogueiras, Horvath, Zorzano, Claret: "Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance." dans: Cell, Vol. 155, Issue 1, pp. 172-87, (2013) (PubMed).

Drivas, Holzbaur, Bennett: "Disruption of CEP290 microtubule/membrane-binding domains causes retinal degeneration." dans: The Journal of clinical investigation, Vol. 123, Issue 10, pp. 4525-39, (2013) (PubMed).

Alger, Rayavarapu, Nagaraju: "Measurement of activation of the endoplasmic reticulum stress response in autoimmune myositis." dans: Methods in enzymology, Vol. 489, pp. 207-25, (2011) (PubMed).

Détails sur ATF4

Antigène: ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))

Autre désignation: ATF4

Sujet:

Background Information: Atf4 binds to asymmetric cAMP response elements (CRE) as a heterodimer and to palindromic CRE's as a homodimer.

Gene Name: Activating transcription factor 4

Alternative Symbols: Atf-, C/AT, CREB, Atf-4, C/ATF, CREB2, CREB-2, TAXREB, TAXREB67

Protein Name: Activating transcriptionn factor 4 EMBL CAA43723.1

Poids moléculaire: 42kDa

ID gène: 11911

NCBI Accession: NP_033846

UniProt: Q61328

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response