JARID2 anticorps (Middle Region)

N° du produit ABIN2780036

Détail du produit anti-JARID2 anticorps

Antigène: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Épitope: Middle Region

Reactivité: Humain, Rat, Souris, Lapin, Cobaye, Chien

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp JARID2 est non-conjugé

Application: Western Blotting (WB)

Séquence: NASSSCQSTP RKGKTHKHVH NGHVFNGSSR SAREKEPAHK HRSKEATPGK

Homologie: Dog: 79%, Guinea Pig: 79%, Human: 79%, Mouse: 100%, Rabbit: 79%, Rat: 79%

Attributs du produit: This is a rabbit polyclonal antibody against Jarid2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of mouse Jarid2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1234 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur JARID2

Antigène: JARID2 (Jumonji, AT Rich Interactive Domain 2 (JARID2))

Autre désignation: Jarid2 (JARID2 Produits)

Synonymes: anticorps JMJ, anticorps Jmj, anticorps jumonji, anticorps JARID2, anticorps jarid2, anticorps jmj, anticorps si:dkey-211c3.1, anticorps Jumonji, anticorps jarid2-a, anticorps jarid2-b, anticorps jarid2.S, anticorps jarid2b, anticorps jumonji and AT-rich interaction domain containing 2, anticorps jumonji, AT rich interactive domain 2, anticorps jumonji, AT rich interactive domain 2a, anticorps jumonji, AT rich interactive domain 2b, anticorps jumonji and AT-rich interaction domain containing 2 L homeolog, anticorps JARID2, anticorps Jarid2, anticorps jarid2a, anticorps jarid2, anticorps jarid2b, anticorps jarid2.L

Sujet: Jarid2 is a regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis.Jarid2 acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes.Jarid2 binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells.Jarid2 does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases.Jarid2 also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5.Jarid2 participates in the negative regulation of cell proliferation signaling.
Alias Symbols: AI317256, AU045941, C79929, C79931, Jmj, jumonji
Protein Interaction Partner: Rb1, Suz12, Ewsr1, Ell, Eed, Aebp2, Morc3, Setx, Stk38l, Thrap3, Ice1, Stk38, Bclaf1, Trim35, Rbbp4, Mtf2, Ezh2, Ezh1,
Protein Size: 1234

Poids moléculaire: 137 kDa

ID gène: 16468

NCBI Accession: NM_021878, NP_068678

UniProt: Q62315

Pathways: Chromatin Binding