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ERCC3 anticorps (N-Term)

ERCC3 Reactivité: Humain, Rat, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio), Cobaye, Porc, Saccharomyces cerevisiae WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN2780326
  • Antigène Voir toutes ERCC3 Anticorps
    ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))
    Épitope
    • 15
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    Humain, Rat, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio), Cobaye, Porc, Saccharomyces cerevisiae
    Hôte
    • 37
    • 8
    • 1
    • 1
    Lapin
    Clonalité
    • 40
    • 7
    Polyclonal
    Conjugué
    • 26
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ERCC3 est non-conjugé
    Application
    • 36
    • 13
    • 13
    • 12
    • 7
    • 7
    • 7
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Séquence
    MGKRDRADRD KKKSRKRHYE DEEDDEEDAP GNDPQEAVPS AAGKQVDESG
    Homologie
    Cow: 86%, Dog: 86%, Guinea Pig: 79%, Human: 100%, Pig: 93%, Rabbit: 79%, Rat: 79%, Yeast: 90%, Zebrafish: 79%
    Attributs du produit
    This is a rabbit polyclonal antibody against ERCC3. It was validated on Western Blot using a cell lysate as a positive control.
    Purification
    Affinity Purified
    Immunogène
    The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC3
    Top Product
    Discover our top product ERCC3 Anticorps primaire
  • Indications d'application
    Optimal working dilutions should be determined experimentally by the investigator.
    Commentaires

    Antigen size: 782 AA

    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Conseil sur la manipulation
    Avoid repeated freeze-thaw cycles.
    Stock
    -20 °C
    Stockage commentaire
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Vijai, Topka, Villano, Ravichandran, Maxwell, Maria, Thomas, Gaddam, Lincoln, Kazzaz, Wenz, Carmi, Schrader, Hart, Lipkin, Neuhausen, Walsh, Zhang, Lejbkowicz, Rennert, Stadler, Robson, Weitzel et al.: "A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. ..." dans: Cancer discovery, Vol. 6, Issue 11, pp. 1267-1275, (2016) (PubMed).

  • Antigène
    ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))
    Autre désignation
    ERCC3 (ERCC3 Produits)
    Synonymes
    anticorps BTF2, anticorps GTF2H, anticorps RAD25, anticorps TFIIH, anticorps XPB, anticorps BTF2 p89, anticorps Ercc-3, anticorps wu:fc25f08, anticorps ERCC excision repair 3, TFIIH core complex helicase subunit, anticorps excision repair cross-complementing rodent repair deficiency, complementation group 3, anticorps excision repair cross-complementation group 3, anticorps ERCC3, anticorps Ercc3, anticorps ercc3
    Sujet
    ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.
    Alias Symbols: BTF2, GTF2H, RAD25, TFIIH, XPB
    Protein Interaction Partner: XIAP, CEP70, UBC, rev, SRPK2, CDK7, TP53, E2F1, CDK8, CCNC, GTF2H5, ERCC2, MSANTD2, UVSSA, POLR2C, KPNA3, RAD52, MMS19, SIX5, GTF2H4, GTF2H3, GTF2H1, tat, COPS2, GTF2H2, NEDD8, ERCC6, POLR2A, AR, CCNH, MYC, MNAT1, ZSCAN1, ATF7IP, GCN1L1, ERCC5, BCR, PSMC5
    Protein Size: 782
    Poids moléculaire
    89 kDa
    ID gène
    2071
    NCBI Accession
    NM_000122, NP_000113
    UniProt
    P19447
    Pathways
    Réparation de l'ADN
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