ERCC3 anticorps (N-Term)

N° du produit ABIN2780326

Il existe 1 publication pour ce produit. L’anticorps anti-ERCC3 Polyclonal Lapin est utilisé pour la détection de ERCC3 dans des échantillons de Humain, Rat, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio), Cobaye, Porc et Saccharomyces cerevisiae. Il a été validé pour WB.

Aperçu rapide pour ERCC3 anticorps (N-Term) (ABIN2780326)

Antigène: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Reactivité: Humain, Rat, Boeuf (Vache), Chien, Lapin, Poisson zèbre (Danio rerio), Cobaye, Porc, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ERCC3 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ERCC3 anticorps

Épitope: N-Term

Fonction: ERCC3 Antibody - N-terminal region

Séquence: MGKRDRADRD KKKSRKRHYE DEEDDEEDAP GNDPQEAVPS AAGKQVDESG

Homologie: Cow: 86%, Dog: 86%, Guinea Pig: 79%, Human: 100%, Pig: 93%, Rabbit: 79%, Rat: 79%, Yeast: 90%, Zebrafish: 79%

Attributs du produit: This is a rabbit polyclonal antibody against ERCC3. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human ERCC3

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Commentaires:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP37963-100UG

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: prevent freeze-thaw cycles

Stock: 4 °C,-20 °C

Stockage commentaire: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-ERCC3 (ABIN2780326)

Vijai, Topka, Villano, Ravichandran, Maxwell, Maria, Thomas, Gaddam, Lincoln, Kazzaz, Wenz, Carmi, Schrader, Hart, Lipkin, Neuhausen, Walsh, Zhang, Lejbkowicz, Rennert, Stadler, Robson, Weitzel et al.: "A Recurrent ERCC3 Truncating Mutation Confers Moderate Risk for Breast Cancer. ..." dans: Cancer discovery, Vol. 6, Issue 11, pp. 1267-1275, (2016) (PubMed).

Détails sur ERCC3

Antigène: ERCC3 (DNA Repair Protein Complementing XP-B Cells (ERCC3))

Autre désignation: ERCC3

Sujet:

Background Information: ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.

Gene Name: Excision repair cross-complementing rodent repair deficiency, complementation group 3

Alternative Symbols: XPB, BTF2, Ssl2, TTD2, GTF2H, RAD25, TFIIH

Protein Name: TFIIH basal transcription factor complex helicase XPB subunit

Poids moléculaire: 89kDa

ID gène: 2071

NCBI Accession: NP_000113

UniProt: P19447

Pathways: Réparation de l'ADN