NR4A2 anticorps (N-Term)

N° du produit ABIN2780752

Détail du produit anti-NR4A2 anticorps

Antigène: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Poisson zèbre (Danio rerio), Chien, Cobaye, Cheval, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR4A2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: MPCVQAQYGS SPQGASPASQ SYSYHSSGEY SSDFLTPEFV KFSMDLTNTE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against NR4A2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human NR4A2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 598 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-NR4A2 (ABIN2780752)

Brami-Cherrier, Anzalone, Ramos, Forne, Macciardi, Imhof, Borrelli: "Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits." dans: Molecular psychiatry, Vol. 19, Issue 11, pp. 1193-200, (2014) (PubMed).

Détails sur NR4A2

Antigène: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Autre désignation: NR4A2 (NR4A2 Produits)

Synonymes: anticorps nr41/42/43, anticorps Nr4a2, anticorps nurr1, anticorps not, anticorps rnr1, anticorps hzf-3, anticorps tinur, anticorps NGFI-B, anticorps HZF-3, anticorps NOT, anticorps NURR1, anticorps RNR1, anticorps TINUR, anticorps Nurr1, anticorps RNR-1, anticorps TINOR, anticorps ngf1b, anticorps nr4a2, anticorps zgc:92696, anticorps nuclear receptor subfamily 4 group A member 2, anticorps nuclear receptor, anticorps nuclear receptor subfamily 4, group A, member 2, anticorps nuclear receptor subfamily 4, group A, member 2b, anticorps NR4A2, anticorps nr41/42/43, anticorps nr4a2, anticorps Nr4a2, anticorps nr4a2b

Sujet: NR4A2 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. The protein may act as a transcription factor. Mutations in NR4A2 gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of NR4A2 gene may be associated with rheumatoid arthritis.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined.This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: HZF-3, NOT, NURR1, RNR1, TINUR
Protein Interaction Partner: CDKN2D, TCEAL5, BAZ1B, ELAVL1, COPS5, RXRB, RXRA, RUNX1, SMARCA4, SMARCA2, SIN3A, NCOR2, SFPQ, PIAS4, RPS6KA1, CDKN1C, RARB, RARA, CREB1,
Protein Size: 598

Poids moléculaire: 66 kDa

ID gène: 4929

NCBI Accession: NM_006186, NP_006177

UniProt: P43354

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway