NR4A2 anticorps (AA 13-42)

N° du produit ABIN3032065

Détail du produit anti-NR4A2 anticorps

Antigène: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Épitope: AA 13-42

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NR4A2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Réactivité croisée (Details): Expected species reactivity: Rat, Bovine

Purification: Purified

Immunogène: A portion of amino acids 13-42 from the human protein was used as the immunogen for this NURR1 antibody.

Isotype: Ig Fraction

Information d'application

Indications d'application: Titration of the NURR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:10-1:50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the NURR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Détails sur NR4A2

Antigène: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Autre désignation: NURR1 (NR4A2 Produits)

Synonymes: anticorps nr41/42/43, anticorps Nr4a2, anticorps nurr1, anticorps not, anticorps rnr1, anticorps hzf-3, anticorps tinur, anticorps NGFI-B, anticorps HZF-3, anticorps NOT, anticorps NURR1, anticorps RNR1, anticorps TINUR, anticorps Nurr1, anticorps RNR-1, anticorps TINOR, anticorps ngf1b, anticorps nr4a2, anticorps zgc:92696, anticorps nuclear receptor subfamily 4 group A member 2, anticorps nuclear receptor, anticorps nuclear receptor subfamily 4, group A, member 2, anticorps nuclear receptor subfamily 4, group A, member 2b, anticorps NR4A2, anticorps nr41/42/43, anticorps nr4a2, anticorps Nr4a2, anticorps nr4a2b

Sujet: Parkinson's disease (PD) is a multifactorial disease that appears to arise from the effects of both genetic and environmental influences. The known genetic factors include multiple genes that have been identified in related parkinsonian syndromes, as well as alpha-synuclein. Genes associated with either PD or Parkinson-related disorders include parkin, DJ-1, ubiquitin C-terminal hydrolase isozyme L1 (UCH-L1), nuclear receptor-related factor 1 (NURR1), and alpha-synuclein. Nurr1 is a transcription factor that is expressed in the embryonic ventral midbrain and is critical for the development of dopamine (DA) neurons. It belongs to the conserved family of nuclear receptors but lacks an identified ligand and is therefore referred to as an orphan receptor. RXR ligands can promote the survival of DA neurons via a process that depends on Nurr1-RXR heterodimers. In developing DA cells, Nurr1 is required for the expression of several genes important for DA synthesis and function. Nurr1 is also important for the maintenance of adult DA neurons.

UniProt: P43354

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway