MARCH8 anticorps (Middle Region)

N° du produit ABIN2781250

Détail du produit anti-MARCH8 anticorps

Antigène: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MARCH8 est non-conjugé

Application: Western Blotting (WB)

Séquence: YVQCKVYVQL WKRLKAYNRV IYVQNCPETS KKNIFEKSPL TEPNFENKHG

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against MARCH8. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human MARCH8

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 291 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MARCH8

Antigène: MARCH8 (Membrane-Associated Ring Finger (C3HC4) 8, E3 Ubiquitin Protein Ligase (MARCH8))

Autre désignation: MARCH8 (MARCH8 Produits)

Synonymes: anticorps MARCH-VIII, anticorps MIR, anticorps RNF178, anticorps c-MIR, anticorps zgc:171495, anticorps 1300017E09Rik, anticorps Mir, anticorps Mar-08, anticorps MARCH8, anticorps membrane associated ring-CH-type finger 8, anticorps membrane-associated ring finger (C3HC4) 8, anticorps membrane associated ring-CH-type finger 8 L homeolog, anticorps MARCH8, anticorps march8, anticorps March8, anticorps march8.L

Sujet: MARCH8 is an E3 ubiquitin-protein ligase that may regulate immune responses by promoting ubiquitination of MHC-II and CD86, which leads to their subsequent endocytosis and lysosomal degradation. It may also promote ubiquitination and endocytosis of TFRC and FAS. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Alias Symbols: MARCH-VIII, MIR, RNF178, c-MIR
Protein Interaction Partner: TNFRSF10A, UBC, UBE2H, UBE2D1, TFRC, UBE2D3, IL1RAP, IL1R1, CD86,
Protein Size: 291

Poids moléculaire: 33 kDa

ID gène: 220972

NCBI Accession: NM_145021, NP_659458

UniProt: Q5T0T0