SLC11A1 anticorps (Middle Region)

N° du produit ABIN2781544

Détail du produit anti-SLC11A1 anticorps

Antigène: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Épitope: Middle Region

Reactivité: Humain, Rat, Boeuf (Vache), Cobaye, Lapin, Chévre, Cheval, Mouton

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SLC11A1 est non-conjugé

Application: Western Blotting (WB)

Séquence: GYEYVVARPE QGALLRGLFL PSCPGCGHPE LLQAVGIVGA IIMPHNIYLH

Homologie: Cow: 86%, Goat: 86%, Guinea Pig: 93%, Horse: 86%, Human: 100%, Rabbit: 93%, Rat: 86%, Sheep: 86%

Attributs du produit: This is a rabbit polyclonal antibody against SLC11A1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of Human SLC11A1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur SLC11A1

Antigène: SLC11A1 (Solute Carrier Family 11 (Proton-Coupled Divalent Metal Ion Transporters), Member 1 (SLC11A1))

Autre désignation: SLC11A1 (SLC11A1 Produits)

Synonymes: anticorps SLC11A1, anticorps NRAMP1, anticorps LSH, anticorps NRAMP, anticorps Bcg, anticorps Itg, anticorps Lsh, anticorps Nramp1, anticorps Ity, anticorps Nramp, anticorps ity, anticorps BCG, anticorps solute carrier family 11 member 1 L homeolog, anticorps solute carrier family 11 member 1, anticorps solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1, anticorps slc11a1.L, anticorps SLC11A1, anticorps Slc11a1

Sujet: SLC11A1 is a divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. It controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe2+ and Mn2+, cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes.
Alias Symbols: LSH, NRAMP, NRAMP1
Protein Size: 550

Poids moléculaire: 60 kDa

ID gène: 6556

NCBI Accession: NM_000578, NP_000569

UniProt: P49279

Pathways: Transition Metal Ion Homeostasis, Production of Molecular Mediator of Immune Response, Protein targeting to Nucleus