SRD5A2 anticorps (N-Term)

N° du produit ABIN2781789

Détail du produit anti-SRD5A2 anticorps

Antigène: SRD5A2 (Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Porc, Chien, Cheval, Lapin, Boeuf (Vache)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRD5A2 est non-conjugé

Application: Western Blotting (WB)

Séquence: KHTESLKPAA TRLPARAAWF LQELPSFAVP AGILARQPLS LFGPPGTVLL

Homologie: Cow: 100%, Dog: 100%, Horse: 100%, Human: 100%, Mouse: 77%, Pig: 93%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against SRD5A2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human SRD5A2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 254 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Références pour anticorps anti-SRD5A2 (ABIN2781789)

Bertin, Dury, Ouellet, Pelletier, Labrie: "Localization of the androgen-synthesizing enzymes, androgen receptor, and sex steroids in the vagina: possible implications for the treatment of postmenopausal sexual dysfunction." dans: The journal of sexual medicine, Vol. 11, Issue 8, pp. 1949-61, (2014) (PubMed).

Détails sur SRD5A2

Antigène: SRD5A2 (Steroid-5-alpha-Reductase, alpha Polypeptide 2 (3-Oxo-5 alpha-Steroid delta 4-Dehydrogenase alpha 2) (SRD5A2))

Autre désignation: SRD5A2 (SRD5A2 Produits)

Synonymes: anticorps S5AR 2, anticorps 5ART2, anticorps SRD5alpha2, anticorps SRD5A2, anticorps Srd5a2, anticorps CH73-233A22.6, anticorps wu:fk70d02, anticorps zgc:109942, anticorps zgc:112208, anticorps zgc:112455, anticorps steroid 5 alpha-reductase 2, anticorps steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2), anticorps 3-oxo-5-alpha-steroid 4-dehydrogenase 2, anticorps steroid-5-alpha-reductase, alpha polypeptide 2a, anticorps steroid-5-alpha-reductase, alpha polypeptide 2b, anticorps SRD5A2, anticorps Srd5a2, anticorps srd5a2, anticorps LOC100125532, anticorps srd5a2a, anticorps srd5a2b

Sujet: This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH).
Alias Symbols: MGC138457
Protein Size: 254

Poids moléculaire: 28 kDa

ID gène: 6716

NCBI Accession: NM_000348, NP_000339

UniProt: P31213

Pathways: Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis