ATP2B4 anticorps (Middle Region)

N° du produit ABIN2781844

Détail du produit anti-ATP2B4 anticorps

Antigène: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Cobaye, Cheval, Lapin, Boeuf (Vache), Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ATP2B4 est non-conjugé

Application: Western Blotting (WB)

Séquence: FAGEKFFDID SGRKAPLHSP PSQHYTIVFN TFVLMQLFNE INSRKIHGEK

Homologie: Cow: 93%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 93%, Rabbit: 100%, Rat: 100%, Zebrafish: 86%

Attributs du produit: This is a rabbit polyclonal antibody against ATP2B4. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ATP2B4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 1170 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ATP2B4

Antigène: ATP2B4 (ATPase, Ca++ Transporting, Plasma Membrane 4 (ATP2B4))

Autre désignation: ATP2B4 (ATP2B4 Produits)

Synonymes: anticorps ATP2B2, anticorps MXRA1, anticorps PMCA4, anticorps PMCA4b, anticorps PMCA4x, anticorps atp2b2, anticorps atp2b3, anticorps mxra1, anticorps pmca4, anticorps pmca4b, anticorps pmca4x, anticorps zgc:152801, anticorps ATP2B4, anticorps ATP2B1, anticorps Pmca4, anticorps ATPase plasma membrane Ca2+ transporting 4, anticorps ATPase, Ca++ transporting, plasma membrane 4 L homeolog, anticorps ATPase, Ca++ transporting, plasma membrane 4, anticorps ATP2B4, anticorps atp2b4.L, anticorps atp2b4, anticorps Atp2b4

Sujet: ATP2B4 belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. ATP2B4 is the plasma membrane calcium ATPase isoform 4.The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 4. Alternatively spliced transcript variants encoding different isoforms have been identified.
Alias Symbols: ATP2B2, DKFZp686G08106, DKFZp686M088, MXRA1, PMCA4, PMCA4b, PMCA4x
Protein Interaction Partner: UBC, CDK7, ADRB2, ERBB2IP, RASSF1, DLG2, DLG4, DLG1, DLG3, CASK, SRC, NOS1, PPP3CA, CD22, PDZD11,
Protein Size: 1170

Poids moléculaire: 129 kDa

ID gène: 493

NCBI Accession: NM_001001396, NP_001001396

UniProt: B1APW5

Pathways: Ribonucleoside Biosynthetic Process