ITM2C anticorps (Middle Region)

N° du produit ABIN970977

Détail du produit anti-ITM2C anticorps

Antigène: ITM2C (Integral Membrane Protein 2C (ITM2C))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Mouton, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ITM2C est non-conjugé

Application: Western Blotting (WB)

Séquence: EDSLSSQVRT QMELEEDVKI YLDENYERIN VPVPQFGGGD PADIIHDFQR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 93%, Rat: 100%, Sheep: 100%, Zebrafish: 91%

Attributs du produit: This is a rabbit polyclonal antibody against ITM2C. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 267 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ITM2C

Antigène: ITM2C (Integral Membrane Protein 2C (ITM2C))

Autre désignation: ITM2C (ITM2C Produits)

Synonymes: anticorps 3110038L02Rik, anticorps BRI3, anticorps Bricd2c, anticorps E25, anticorps E25C, anticorps ITM3, anticorps BRICD2C, anticorps fj35c02, anticorps itm2c, anticorps wu:fj35c02, anticorps zgc:66349, anticorps wu:fj52a04, anticorps zgc:92783, anticorps integral membrane protein 2C, anticorps integral membrane protein 2Cb, anticorps integral membrane protein 2Ca, anticorps Itm2c, anticorps ITM2C, anticorps itm2cb, anticorps itm2ca

Sujet: ITM2C is a negative regulator of beta amyloid peptide production. ITM2C may inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor.ITM2C may play a role in TNF-induced cell death and neuronal differentiation.
Alias Symbols: BRI3, BRICD2C, E25, E25C, ITM3
Protein Interaction Partner: UBC, Dlg4, RYK, BACE1, RNF7, STT3A, MTNR1B, FURIN,
Protein Size: 267

Poids moléculaire: 30 kDa

ID gène: 81618

NCBI Accession: NM_030926, NP_112188

UniProt: Q9NQX7