PILRB anticorps (Middle Region)

N° du produit ABIN2782794

Détail du produit anti-PILRB anticorps

Antigène: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Épitope: Middle Region

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PILRB est non-conjugé

Application: Western Blotting (WB)

Séquence: KLTITQAVTT TTTWRPSSTT TIAGLRVTES KGHSESWHLS LDTAIRVALA

Homologie: Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against PILRB. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PILRB

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 227 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PILRB

Antigène: PILRB (Paired Immunoglobin-Like Type 2 Receptor beta (PILRB))

Autre désignation: PILRB (PILRB Produits)

Synonymes: anticorps FDFACT1, anticorps FDFACT2, anticorps FDFACT, anticorps Fdact, anticorps Pilrb, anticorps paired immunoglobin-like type 2 receptor beta, anticorps paired immunoglobin-like type 2 receptor beta 1, anticorps PILRB, anticorps Pilrb1, anticorps Pilrb

Sujet: Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner and functions in the activating role. Alternative splicing has been observed at this locus and three variants, encoding two distinct isoforms, are described. Additional transcript variants have been identified but their full-length nature has not been determined.
Alias Symbols: FDFACT1, FDFACT2
Protein Interaction Partner: BRCA1, ABHD16A, SAMSN1, PTPN6, PTPN11, LYN,
Protein Size: 227

Poids moléculaire: 23 kDa

ID gène: 29990

NCBI Accession: NM_013440, NP_038468

UniProt: Q9UKJ0