Arrestin 3 anticorps (Middle Region)

N° du produit ABIN2783190

Cet anticorps Lapin Polyclonal détecte spécifiquement Arrestin 3 dans WB et IHC. Il présente une réactivité envers Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cheval, Lapin, Cobaye et Poisson zèbre (Danio rerio).

Aperçu rapide pour Arrestin 3 anticorps (Middle Region) (ABIN2783190)

Antigène: Arrestin 3 (ARRB2) (Arrestin, beta 2 (ARRB2))

Reactivité: Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Cheval, Lapin, Cobaye, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Arrestin 3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-Arrestin 3 anticorps

Épitope: Middle Region

Séquence: RLVIRKVQFA PEKPGPQPSA ETTRHFLMSD RSLHLEASLD KELYYHGEPL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 86%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against ARRB2. It was validated on Western Blot and immunohistochemistry.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human ARRB2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 409 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur Arrestin 3

Antigène: Arrestin 3 (ARRB2) (Arrestin, beta 2 (ARRB2))

Autre désignation: ARRB2

Sujet: Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. ARRB2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors.Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.
Alias Symbols: ARB2, ARR2, DKFZp686L0365, BARR2
Protein Interaction Partner: UBC, SRC, MAPK9, INSR, AKT1, USP33, ADRB2, TBXA2R, CYTH1, PTGDS, BAI1, LIMK1, CFL1, CSK, AGTR1, MAP2K4, MAPK10, MAP3K5, GCG, NFKBIA, MDM2, IGF1R, CLTC, ADRB1, HIPK3, EDNRA, gag-pol, ARRDC3, ARRDC4, SIRT1, PDE4D, Mlnr, Trhr, C5AR1, SLC9A5, AP2M1, HCRTR1, F
Protein Size: 409

Poids moléculaire: 46 kDa

ID gène: 409

NCBI Accession: NM_199004, NP_945355

UniProt: P32121

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, Phototransduction, Thromboxane A2 Receptor Signaling