HFE2 anticorps (N-Term)

N° du produit ABIN2785415

Détail du produit anti-HFE2 anticorps

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Épitope: N-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Lapin, Chien, Cobaye

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HFE2 est non-conjugé

Application: Western Blotting (WB)

Séquence: SSLSIQTANP GNHVEIQAAY IGTTIIIRQT AGQLSFSIKV AEDVAMAFSA

Homologie: Cow: 100%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against HFE2. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N terminal region of human HFE2

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 200 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur HFE2

Antigène: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Autre désignation: HFE2 (HFE2 Produits)

Synonymes: anticorps HFE2A, anticorps HJV, anticorps JH, anticorps RGMC, anticorps HFE2, anticorps DKFZp468F2322, anticorps 2310035L15Rik, anticorps 5230400G09Rik, anticorps AI414844, anticorps AI789733, anticorps DL-M, anticorps Rgmc, anticorps hemojuvelin, anticorps RGMr, anticorps hjv, anticorps id:ibd3464, anticorps wu:fb38f10, anticorps zgc:136698, anticorps hemochromatosis type 2 (juvenile), anticorps hemochromatosis type 2, anticorps HFE2, anticorps Hfe2, anticorps hfe2

Sujet: The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30.
Alias Symbols: HFE2A, HJV, JH, MGC23953, RGMC
Protein Size: 200

Poids moléculaire: 21 kDa

ID gène: 148738

NCBI Accession: NM_202004, NP_973733

UniProt: Q6ZVN8

Pathways: Transition Metal Ion Homeostasis