PSME1 anticorps (Middle Region)

N° du produit ABIN2787720

Détail du produit anti-PSME1 anticorps

Antigène: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Épitope: Middle Region

Reactivité: Humain, Souris, Rat, Chien, Porc, Boeuf (Vache), Lapin, Cobaye, Saccharomyces cerevisiae

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PSME1 est non-conjugé

Application: Western Blotting (WB)

Séquence: KEKEERKKQQ EKEDKDEKKK GEDEDKGPPC GPVNCNEKIV VLLQRLKPEI

Homologie: Cow: 93%, Dog: 93%, Guinea Pig: 93%, Human: 100%, Mouse: 86%, Pig: 100%, Rabbit: 93%, Rat: 93%, Yeast: 83%

Attributs du produit: This is a rabbit polyclonal antibody against PSME1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human PSME1

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 250 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PSME1

Antigène: PSME1 (Proteasome (Prosome, Macropain) Activator Subunit 1 (PA28 Alpha) (PSME1))

Autre désignation: PSME1 (PSME1 Produits)

Synonymes: anticorps fk89d05, anticorps wu:fk89d05, anticorps IFI5111, anticorps PA28A, anticorps PA28alpha, anticorps REGalpha, anticorps AW413925, anticorps PA28a, anticorps proteasome activator subunit 1, anticorps proteasome (prosome, macropain) activator subunit 1 (PA28 alpha), anticorps psme1, anticorps PSME1, anticorps Psme1

Sujet: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified.
Alias Symbols: IFI5111, MGC8628, PA28A, PA28alpha, REGalpha
Protein Interaction Partner: HUWE1, PSME1, NAA10, PSMD14, SHFM1, UBC, PSME2, ADRM1, PSMA1, KIF5B, PARK2, BAG3, UBL7, PSRC1, PARVB, PHPT1, PRDX3, NUBP2, USP5, RBBP6, PSMD12, PSMD1, PSMC4, PSMC2, PSMB3, PSMB2, PSMB1, PSMA7, PSMA6, PSMA3, APP, OXCT1, CSE1L, GRB2, UBD, PSMD6, TUBG1, PSMB
Protein Size: 250

Poids moléculaire: 28 kDa

ID gène: 5720

NCBI Accession: NM_176783, NP_788955

UniProt: Q06323

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA