TLR4 anticorps (Middle Region)

N° du produit ABIN2787920

Détail du produit anti-TLR4 anticorps

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Épitope: Middle Region

Reactivité: Humain, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TLR4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Séquence: LGEFRNEGNL EKFDKSALEG LCNLTIEEFR LAYLDYYLDD IIDLFNCLTN

Homologie: Human: 100%, Pig: 86%

Attributs du produit: This is a rabbit polyclonal antibody against TLR4. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TLR4

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 839 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TLR4

Antigène: TLR4 (Toll-Like Receptor 4 (TLR4))

Autre désignation: TLR4 (TLR4 Produits)

Synonymes: anticorps ARMD10, anticorps CD284, anticorps TLR-4, anticorps TOLL, anticorps Lps, anticorps Ly87, anticorps Ran/M1, anticorps Rasl2-8, anticorps toll like receptor 4, anticorps toll-like receptor 4, anticorps TLR4, anticorps Tlr4

Sujet: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain.
Alias Symbols: ARMD10, CD284, TOLL, hToll
Protein Interaction Partner: TNFSF9, SRC, SYK, SMAD3, SERTAD1, BTK, TICAM1, HGS, UBC, HSPA4, TICAM2, STK11IP, TIRAP, TRAF3, TRIM69, IRAK4, TBK1, STUB1, TRAF6, PRKCZ, MYD88, IRAK1, HSPA8, RNF216, CNPY4, SIGIRR, MAPK8IP3, NOX4, TOLLIP, LY96, BCL10, RIPK2, IRAK2, TLR5, DEFB4A, TLR1, HSP
Protein Size: 839

Poids moléculaire: 93 kDa

ID gène: 7099

NCBI Accession: NM_138554, NP_612564

UniProt: O00206

Pathways: Signalisation TLR, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome, S100 Proteins