PYM anticorps (C-Term)

N° du produit ABIN2788485

Détail du produit anti-PYM anticorps

Antigène: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Épitope: C-Term

Reactivité: Humain, Souris, Boeuf (Vache), Chien, Cheval, Cobaye, Lapin, Rat, Saccharomyces cerevisiae, Porc

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PYM est non-conjugé

Application: Western Blotting (WB)

Séquence: KKIKNLKKKL RQVEELQQRI QAGEVSQPSK EQLEKLARRR ALEEELEDLE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 93%, Pig: 100%, Rabbit: 93%, Rat: 100%, Yeast: 100%

Attributs du produit: This is a rabbit polyclonal antibody against WIBG. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C terminal region of human WIBG

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 204 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur PYM

Antigène: PYM (WIBG) (Partner of Y14 and mago (WIBG))

Autre désignation: WIBG (WIBG Produits)

Synonymes: anticorps BEST:HL05757, anticorps CG10330, anticorps CG30176, anticorps Dmel\\CG30176, anticorps PYM, anticorps Pym, anticorps UD3, anticorps A030010B05Rik, anticorps zgc:65891, anticorps zgc:77281, anticorps Partner of Y14 and Mago, anticorps Wibg protein, anticorps PYM homolog 1, exon junction complex associated factor L homeolog, anticorps PYM homolog 1, exon junction complex associated factor, anticorps Pym, anticorps wibg, anticorps pym1.L, anticorps PYM1, anticorps Pym1, anticorps pym1

Sujet: WIBG is a key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. It acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. It interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions.
Alias Symbols: MGC13064, PYM
Protein Interaction Partner: RTN4IP1, UBC, RPS19, RPS14, RPS13, RPS12, RPS10, RPS9, RPS8, RPS7, RPS6, RPS5, RPS4X, RPS3A, RPS3, RPS2, FAU, BYSL, ZNF503, PNO1, KCMF1, TSR1, RPS27L, UBQLN1, RPS29, RPS28, RPS27, RPS26, RPS25, RPS24, RPS23, RPS20, RPS18, RPS16, RPS15A, TARDBP, MAGOH, TOE
Protein Size: 204

Poids moléculaire: 23 kDa

ID gène: 84305

NCBI Accession: NM_032345, NP_115721

UniProt: Q9BRP8