KLRK1 anticorps (C-Term)

N° du produit ABIN2789432

Détail du produit anti-KLRK1 anticorps

Antigène: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Épitope: C-Term

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp KLRK1 est non-conjugé

Application: Western Blotting (WB)

Séquence: HIPTNGSWQW EDGSILSPNL LTIIEMQKGD CALYASSFKG YIENCSTPNT

Homologie: Cow: 79%, Dog: 86%, Guinea Pig: 91%, Horse: 86%, Human: 100%, Mouse: 92%, Rabbit: 86%, Rat: 93%

Attributs du produit: This is a rabbit polyclonal antibody against KLRK1. It was validated on Western Blot.

Purification: Affinity Purified

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 216 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur KLRK1

Antigène: KLRK1 (Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1))

Autre désignation: KLRK1 (KLRK1 Produits)

Synonymes: anticorps KLRK1, anticorps NKG2D, anticorps CD314, anticorps D12S2489E, anticorps KLR, anticorps NKG2-D, anticorps D6H12S2489E, anticorps Nkg2d, anticorps Nkrp2, anticorps killer cell lectin like receptor K1, anticorps killer cell lectin-like receptor subfamily K, member 1, anticorps NKG2D protein, anticorps KLRK1, anticorps Klrk1, anticorps NKG2D

Sujet: Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.
Alias Symbols: CD314, D12S2489E, FLJ17759, FLJ75772, KLR, NKG2-D, NKG2D
Protein Interaction Partner: KLRK1, RAET1G, RAET1E, ULBP3, HLA-B, TYROBP, HCST, MICB, RAE1,
Protein Size: 216

Poids moléculaire: 24 kDa

ID gène: 22914

NCBI Accession: NM_007360, NP_031386

UniProt: P26718

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process