SPAM1 anticorps (C-Term)
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- Antigène Voir toutes SPAM1 Anticorps
- SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
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Épitope
- C-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SPAM1 est non-conjugé
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Application
- Western Blotting (WB)
- Séquence
- CYSTLSCKEK ADVKDTDAVD VCIADGVCID AFLKPPMETE EPQIFYNASP
- Homologie
- Human: 100%
- Attributs du produit
- This is a rabbit polyclonal antibody against SPAM1. It was validated on Western Blot.
- Purification
- Affinity Purified
- Immunogène
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human SPAM1
- Top Product
- Discover our top product SPAM1 Anticorps primaire
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- Indications d'application
- Optimal working dilutions should be determined experimentally by the investigator.
- Commentaires
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Antigen size: 509 AA
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- Lot specific
- Buffer
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Conseil sur la manipulation
- Avoid repeated freeze-thaw cycles.
- Stock
- -20 °C
- Stockage commentaire
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- Antigène
- SPAM1 (Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) (SPAM1))
- Autre désignation
- SPAM1 (SPAM1 Produits)
- Synonymes
- anticorps AV039194, anticorps Ph-20, anticorps PH-20, anticorps PH20, anticorps HYA1, anticorps HYAL1, anticorps HYAL3, anticorps HYAL5, anticorps SPAG15, anticorps Spam, anticorps XEH1, anticorps spam1, anticorps im:6902904, anticorps zgc:158668, anticorps sperm adhesion molecule 1, anticorps sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) L homeolog, anticorps sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding), anticorps Spam1, anticorps SPAM1, anticorps spam1.L, anticorps spam1
- Sujet
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Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1, another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Alias Symbols: HYA1, HYAL1, HYAL3, HYAL5, MGC26532, PH-20, PH20, SPAG15
Protein Size: 509 - Poids moléculaire
- 58 kDa
- ID gène
- 6677
- NCBI Accession
- NM_153189, NP_694859
- UniProt
- P38567
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