MOB1A anticorps (C-Term)

N° du produit ABIN2790218

Cet anticorps Lapin Polyclonal détecte spécifiquement MOB1A dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin, Chien et Poisson zèbre (Danio rerio).

Aperçu rapide pour MOB1A anticorps (C-Term) (ABIN2790218)

Antigène: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Cobaye, Cheval, Lapin, Chien, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MOB1A est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-MOB1A anticorps

Épitope: C-Term

Séquence: FDSVMQLQEE AHLNTSFKHF IFFVQEFNLI DRRELAPLQE LIEKLGSKDR

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 93%

Attributs du produit: This is a rabbit polyclonal antibody against MOB1A. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the C-terminal region of Human MOB1A

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 216 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur MOB1A

Antigène: MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))

Autre désignation: MOB1A

Sujet: MOB1A is an activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. MOB1A stimulates the kinase activity of STK38 and STK38L. MOB1A acts cooperatively with STK3/MST2 to activate STK38.
Alias Symbols: C2orf6, FLJ10788, FLJ11595, MATS1, MOB1, MOBK1B, Mob4B, MOBKL1B
Protein Interaction Partner: FAM9B, CMTM3, SEPT3, FAM118A, KANK2, TDO2, UBC, HECW2, ANKRD52, AMOT, ANKRD44, DOCK7, LRCH3, RASSF5, DOCK8, MOB2, SAV1, LRCH2, DOCK6, THOC2, PPP6R3, CRLF3, IPO11, LATS2, ANKRD28, LRCH1, STK38L, PPP6R1, RASSF2, PPP6R2, LATS1, YWHAH, STK4, STK3, PTPN14, PPP
Protein Size: 216

Poids moléculaire: 25 kDa

ID gène: 55233

NCBI Accession: NM_018221, NP_060691

UniProt: Q9H8S9