MOB1A anticorps (Internal Region)
-
- Antigène Voir toutes MOB1A (MOBKL1B) Anticorps
- MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
-
Épitope
- Internal Region
-
Reactivité
- Humain, Souris, Rat
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp MOB1A est non-conjugé
-
Application
- ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- MOBKL1B Antibody detects endogenous levels of total MOBKL1B.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human MOBKL1B, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product MOBKL1B Anticorps primaire
-
-
- Indications d'application
- WB 1:500-1:2000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Date de péremption
- 12 months
-
- Antigène
- MOB1A (MOBKL1B) (MOB1, Mps One Binder Kinase Activator-Like 1B (MOBKL1B))
- Autre désignation
- MOB1A (MOBKL1B Produits)
- Synonymes
- anticorps mob1, anticorps mob4b, anticorps MOB1A, anticorps MOBK1B, anticorps MOB1, anticorps mats1, anticorps mobk1b, anticorps mobkl1b, anticorps MOBKL1B, anticorps wu:fv69d04, anticorps zgc:56189, anticorps C2orf6, anticorps MATS1, anticorps Mob4B, anticorps 4022402H07Rik, anticorps MOB4B, anticorps Mobk1b, anticorps Mobkl1b, anticorps MOB kinase activator 1A L homeolog, anticorps MOB kinase activator 1A, anticorps MOB kinase activator 1A pseudogene, anticorps mob1a.L, anticorps MOB1A, anticorps mob1a, anticorps LOC712156, anticorps Mob1a
- Sujet
-
Description: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.
Gene: MOB1A
- Poids moléculaire
- 25 kDa
- ID gène
- 55233
- UniProt
- Q9H8S9
-