TRADD anticorps (Middle Region)

N° du produit ABIN2792121

Cet anticorps anti-TRADD est un anticorps Lapin Polyclonal détectant TRADD dans WB. Adapté pour Humain, Chien et Cheval.

Aperçu rapide pour TRADD anticorps (Middle Region) (ABIN2792121)

Antigène: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Reactivité: Humain, Chien, Cheval

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp TRADD est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-TRADD anticorps

Épitope: Middle Region

Séquence: YEQAFQLLRR FVQAEGRRAT LQRLVEALEE NELTSLAEDL LGLTDPNGGL

Homologie: Dog: 76%, Horse: 76%, Human: 100%

Attributs du produit: This is a rabbit polyclonal antibody against TRADD. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the middle region of human TRADD

Information d'application

Indications d'application: Optimal working dilutions should be determined experimentally by the investigator.

Commentaires:

Antigen size: 312 AA

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeated freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur TRADD

Antigène: TRADD (TNFRSF1A-Associated Via Death Domain (TRADD))

Autre désignation: TRADD

Sujet: TRADD is the adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
Alias Symbols: Hs.89862, MGC11078
Protein Interaction Partner: FADD, UBC, TNF, RIPK1, TNFRSF1A, ZMYND11, TOMM70A, PDLIM7, LRRK2, OPTN, TRADD, TRAF2, TRAF1, TNFRSF1B, GFRA1, CHUK, FAS, DAB2IP, EDAR, CDKN2A, TRIP12, LMP1, CASP8, SH3KBP1, USP2, TNFRSF25, PPP2R1A, TRPC4AP, HIPK2, TNFRSF21, CNTRL, TNFRSF10B, TNFRSF10A, BC
Protein Size: 312

Poids moléculaire: 34 kDa

ID gène: 8717

NCBI Accession: NM_003789, NP_003780

UniProt: Q15628

Pathways: Signalisation NF-kappaB, Apoptose, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Hepatitis C