EGF anticorps (AA 956-985)

N° du produit ABIN2793119

L’anticorps Lapin Polyclonal anti-EGF a été validé pour WB. Il convient pour détecter EGF dans des échantillons de Humain.

Aperçu rapide pour EGF anticorps (AA 956-985) (ABIN2793119)

Antigène: EGF (Epidermal Growth Factor (EGF))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EGF est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-EGF anticorps

Épitope: AA 956-985

Fonction: Rabbit Anti-Human EGFR (Y978) Antibody

Immunogène: This EGFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 956-985 amino acids from human EGFR.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot
Recommended Dilutions
WB: 1:1000Western blot analysis of EGFR (arrow) using rabbit polyclonal EGFR Antibody .

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.5 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur EGF

Antigène: EGF (Epidermal Growth Factor (EGF))

Autre désignation: EGF

Sujet:

Target Description: EGFR is a transmembrane glycoprotein that is a member of a family of protein tyrosine kinases crucial in maintaining a normal balance in cell growth and development. A prototype member of the type 1 receptor tyrosine kinases, EGFR is encoded by the cellular oncogene cerbB1. EGFR has an extracellular ligand binding domain, a single transmembrane region, and cytoplasmic domain which is composed of a tyrosine kinase domain and a carboxy terminal domain. The carboxy terminal domain contains at least four tyrosine autophosphorylation sites. Increased production or activation of EGFR has been associated with poor prognosis in a variety of tumors. EGFR overexpression is observed in tumors of the head and neck, brain, bladder, stomach, breast, lung, endometrium, cervix, vulva, ovary, esophagus, stomach and in squamous cell carcinoma.

Gene Symbol: EGFR

Poids moléculaire: 134277 Da

ID gène: 1956

UniProt: P00533

Pathways: Signalisation NF-kappaB, Signalisation RTK, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Carbohydrate Metabolic Process, Hepatitis C, Protein targeting to Nucleus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation