PKN beta anticorps (C-Term)

N° du produit ABIN2793292

Détail du produit anti-PKN beta anticorps

Antigène: PKN beta

Épitope: AA 463-492, C-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PKN beta est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Fonction: Rabbit Anti-Human PKN beta (C-term) Antibody

Immunogène: This PKN beta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 463-492 amino acids from the C-terminal region of human PKN beta.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:10-50Western blot analysis of anti-PKN-beta Pab , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry, clinical relevance has not been evaluated.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1.930 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur PKN beta

Antigène: PKN beta

Abstract: PKN beta Produits

Sujet:

Target Description: PKN3, a protein kinase C-related molecule, mediates malignant cell growth downstream of activated PI3K. PKN3 is required for invasive prostate cell growth as assessed by 3D cell culture assays and in an orthotopic mouse tumor model by inducible expression of short hairpin RNA (shRNA). PKN3 is regulated by PI3K at both the expression level and the catalytic activity level. Therefore, PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of PI3K.

Gene Symbol: PKN3

Poids moléculaire: 99421 Da

ID gène: 29941

UniProt: Q6P5Z2