BRISC and BRCA1 A Complex Member 1 (BABAM1) (AA 9-37), (N-Term) anticorps
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- Antigène Voir toutes BRISC and BRCA1 A Complex Member 1 (BABAM1) Anticorps
- BRISC and BRCA1 A Complex Member 1 (BABAM1)
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Épitope
- AA 9-37, N-Term
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Inconjugué
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Fonction
- Rabbit Anti-Human HSPC142 (N-term) Antibody
- Immunogène
- This HSPC142 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 9-37 amino acids from the N-terminal region of human HSPC142.
- Isotype
- Ig Fraction
- Top Product
- Discover our top product BABAM1 Anticorps primaire
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- Indications d'application
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Western Blot, Immunohistochemistry
Recommended Dilutions
WB: 1:1000, IHC: 1:50-100HSPC142 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. - Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.5 mg/mL
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C (short-term), -20°C (long-term)
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- Antigène
- BRISC and BRCA1 A Complex Member 1 (BABAM1)
- Autre désignation
- HSPC142 (BABAM1 Produits)
- Synonymes
- anticorps merit40, anticorps nba1, anticorps zgc:100909, anticorps c19orf62, anticorps C19orf62, anticorps MERIT40, anticorps NBA1, anticorps C7H19orf62, anticorps 5430437P03Rik, anticorps Merit40, anticorps BRISC and BRCA1 A complex member 1, anticorps BRISC and BRCA1 A complex member 1 L homeolog, anticorps babam1, anticorps BABAM1, anticorps babam1.L, anticorps Babam1
- Sujet
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Target Description: HSPC142 is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. HSPC142 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component
Gene Symbol: BABAM1
- Poids moléculaire
- 36560 Da
- ID gène
- 29086
- UniProt
- Q9NWV8
- Pathways
- Positive Regulation of Response to DNA Damage Stimulus
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