EPS15 anticorps (N-Term)

N° du produit ABIN2796356

Détail du produit anti-EPS15 anticorps

Antigène: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Épitope: AA 186-216, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPS15 est non-conjugé

Application: Western Blotting (WB)

Fonction: Rabbit Anti-Human EPS15R (N-term) Antibody

Immunogène: This EPS15R antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-216 amino acids from the N-terminal region of human EPS15R.

Isotype: Ig Fraction

Information d'application

Indications d'application: Western Blot
Recommended Dilutions
WB: 1:1000The anti-EPS15R Pab is used in Western blot to detect EPS15R in Y79 cell lysate.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 2.0 mg/mL

Stock: 4 °C,-20 °C

Stockage commentaire: 2-8°C (short-term), -20°C (long-term)

Détails sur EPS15

Antigène: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Autre désignation: EPS15 (EPS15 Produits)

Synonymes: anticorps AF-1P, anticorps AF1P, anticorps MLLT5, anticorps CG16932, anticorps Dmel\\CG16932, anticorps EH1, anticorps EPS-15, anticorps Eps15, anticorps anon-WO0118547.85, anticorps eps-15, anticorps eps15, anticorps i31, anticorps 2410112D09Rik, anticorps RGD1307641, anticorps epidermal growth factor receptor pathway substrate 15, anticorps Epidermal growth factor receptor pathway substrate clone 15, anticorps hypothetical protein, anticorps EPS15, anticorps Eps-15, anticorps eps15, anticorps Eps15, anticorps PGTG_06574

Sujet:

Target Description: Ubiquitin is a 76 amino acid highly conserved eukaryotic polypeptide that selectively marks cellular proteins for proteolytic degradation by the 26S proteasome. The process of target selection, covalent attachment and shuttle to the 26S proteasome is a vital means of regulating the concentrations of key regulatory proteins in the cell by limiting their lifespans. Polyubiquitination is a common feature of this modification. Serial steps for modification include the activation of ubiquitin, an ATP-dependent formation of a thioester bond between ubiquitin and the enzyme E1, transfer by transacylation of ubiquitin from E1 to the ubiquitin conjugating enzyme E2, and covalent linkage to the target protein directly by E2 or via E3 ligase enzyme. Deubiquitination enzymes also exist to reverse the marking of protein substrates. Posttranslational tagging by Ub is involved in a multitude of cellular processes, including the cell cycle, cell growth and differentiation, embryogenesis, apoptosis, signal transduction, DNA repair, regulation of transcription and DNA replication, transmembrane transport, stress responses, the immune response, and nervous system functions.

Gene Symbol: EPS15L1

Poids moléculaire: 94255 Da

ID gène: 58513

UniProt: Q9UBC2

Pathways: EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation